Protein Domain : IPR002956

Type:  Family Name:  Bride of sevenless protein
Description:  During development of the Drosophila retina, the bride of sevenless (boss) gene is required in photoreceptor neuron R8 for the development ofphotoreceptor neuron R7, suggesting that boss encodes or regulates an R7-specific inductive cue []. The induction of R8 photoreceptor neuronneighbouring cells to assume an R7 cell fate is believed to be mediated by a direct interaction of boss with sevenless [, ]. An alternative model hasbeen proposed in which the boss protein functions as a receptor, based on a (superficial) similarity to the G-protein-coupled family of membrane receptors []. The boss gene encodes a protein of 896 amino acids with a putative N-terminal signal sequence, a large N-terminal extra-cellular domain, seventransmembrane (TM) segments and a C-terminal cytoplasmic tail [, ]. Theboss protein from Drosophila virilis(Fruit fly) shares a high level of amino acid identity with the Drosophila melanogaster(Fruit fly) homologue, with highest levels of similarity in the TM domains []. Short Name:  Bride_of_7less
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0 Child Features

1 Contains

DB identifier Type Name
IPR017978 Domain GPCR, family 3, C-terminal

1 Cross References

Identifier
PR01223

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0005118 IPR002956
GO:0007601 IPR002956
GO:0016020 IPR002956

3 Ontology Annotations

GO Term Gene Name
GO:0005118 IPR002956
GO:0007601 IPR002956
GO:0016020 IPR002956

0 Parent Features

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Solyc01g034180.1.1 PAC:36138040 Solanum lycopersicum 998  
Solyc12g062970.1.1 PAC:36148384 Solanum lycopersicum 782  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2276620
            1857416
            8506350