| Type: | Family | Name: | Deoxyhypusine synthase, putative, archaeal |
| Description: | Eukaryotic initiation factor 5A (eIF-5A), now considered to be an elongation factor (see ), contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in thepost-translational formation of hypusine is catalysed by the enzyme deoxyhypusine synthase (DS) . The enzyme catalyses the following reaction: Spermidine + [eIF-5A]-lysine = 1,3-diaminopropane + [eIF-5A]-deoxyhypusine The modified version of eIF-5A, and DS, are required for eukaryotic cell proliferation []. The structure is known for this enzyme [] in complex with its NAD+cofactor. This entry represents probable deoxyhypusine synthases from archaea. | Short Name: | Deoxyhypus_synthase_arc |
