| Type: | Family | Name: | DOCK1 homologue |
| Description: | This family includes Dock (Dedicator Of CytoKinesis) proteins from fungi and lower metazoa. Saccharomyces cerevisiae Dck1 (YLR422W) included in this entry is a homologue of human DOCK1. Similar to human Dock/ELMO complex, Dck1 and Lmo1 (Elmo) form an active complex, which acts as a guanine nucleotide exchange factor (GEF) for small GTPase Rho5 []. Under Oxidative stress, the Dck1/Lmo1/Rho5 complex relocates to mitochondria. The Dck1/Lmo1/Rho5 signalling may be involved in triggering cell death as a response to oxidative stress []. | Short Name: | DOCK1_homologue |
