Protein Domain : IPR014920

Type:  Domain Name:  Nuclear receptor coactivator, Ncoa-type, interlocking
Description:  This entry represents the interlocking domain of the eukaryotic nuclear receptor coactivators Ncoa1, Ncoa2 and Ncoa3. The interlocking domain forms a 3-helical non-globular array that forms interlocked heterodimers with its target.Nuclear receptors are ligand-activated transcription factors involved in the regulation of many processes, including development, reproduction and homeostasis. Nuclear receptor coactivators act to modulate the function of nuclear receptors. Coactivators associate with promoters and enhancers primarily through protein-protein contacts to facilitate the interaction between DNA-bound transcription factors and the transcription machinery. In addition to their role as coactivators of various nuclear receptors, Ncoa1 and Ncoa3 both have histone acetyltransferase activity (), but Ncoa2 does not [, ]. Short Name:  Nuc_rcpt_coact_Ncoa-typ
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0 Child Features

0 Contains

1 Cross References

Identifier
PF08815

1 Found In

DB identifier Type Name
IPR017426 Family Nuclear receptor coactivator

4 GO Annotations

GO Term Gene Name
GO:0003713 IPR014920
GO:0035257 IPR014920
GO:0006355 IPR014920
GO:0005634 IPR014920

4 Ontology Annotations

GO Term Gene Name
GO:0003713 IPR014920
GO:0035257 IPR014920
GO:0006355 IPR014920
GO:0005634 IPR014920

1 Parent Features

DB identifier Type Name
IPR009110 Domain Nuclear receptor coactivator, interlocking

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14757047
            15145939