Protein Domain : IPR009110

Type:  Domain Name:  Nuclear receptor coactivator, interlocking
Description:  This entry represents the interlocking domain of various eukaryotic nuclear receptor coactivators, including CREBP, P300, Ncoa1, Ncoa2 and Ncoa3. The interlocking domain forms a 3-helical non-globular array that forms interlocked heterodimers with its target.Nuclear receptors are ligand-activated transcription factors involved in the regulation of many processes, including development, reproduction and homeostasis. Nuclear receptor coactivators act to modulate the function of nuclear receptors. Coactivators associate with promoters and enhancers primarily through protein-protein contacts to facilitate the interaction between DNA-bound transcription factors and the transcription machinery. Many of these coactivators are structurally related, including CBP (CREB-binding protein), P300 and ACTR (activator for thyroid and retinoid receptors) []. CBP and P300 both have histone acetyltransferase activity (). CBP/P300 proteins function synergistically to activate transcription, acting to remodel chromatin and to recruit RNA polymerase II and the basal transcription machinery. CBP is required for proper cell cycle control, differentiation and apoptosis. The interaction of CBP/P300 with transcription factors involves several small domains. The IBiD domain in the C-terminal of CBP is responsible for CBP interaction with IRF-3, as well as with the adenoviral oncoprotein E1A, TIF-2 coactivator, and the IRF homologue KSHV IRF-1 [].Ncoa1, Ncoa2 and Ncoa3 are all coactivators of various nuclear receptors. In addition, Ncoa1 and Ncoa3 both have histone acetyltransferase activity, but Ncoa2 does not [, ]. Short Name:  Nuc_rcpt_coact
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2 Child Features

DB identifier Type Name
IPR014744 Domain Nuclear receptor coactivator, CREB-bp-like, interlocking
IPR014920 Domain Nuclear receptor coactivator, Ncoa-type, interlocking

0 Contains

1 Cross References

Identifier
SSF69125

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003713 IPR009110
GO:0006355 IPR009110
GO:0005634 IPR009110

3 Ontology Annotations

GO Term Gene Name
GO:0003713 IPR009110
GO:0006355 IPR009110
GO:0005634 IPR009110

0 Parent Features

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
113644 D8SCP9 PAC:15417787 Selaginella moellendorffii 274  
Glyma.09G136100.1.p I1L354 PAC:30486734 Glycine max 259  
Pp3c17_9970V3.1.p A9SQY1 PAC:32905688 Physcomitrium patens 109  
evm.model.AsparagusV1_02.570 A0A5P1FG73 PAC:40541482 Asparagus officinalis 439  
Glyma.09G136100.1.p I1L354 PAC:41135590 Glycine max 259  
GlymaLee.09G106500.1.p I1L354 PAC:41274605 Glycine max Lee 259  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11823864
            11583620
            14757047
            15145939