1 Parent Features
| DB identifier | Type | Name |
|---|---|---|
| IPR000336 | Domain | Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain |
| Type: | Domain | Name: | Flavivirus glycoprotein, immunoglobulin-like domain |
| Description: | Flaviruses are small, enveloped RNA viruses that use arthropods such as mosquitoes for transmission to their vertebrate hosts, and include Yellow fever virus, West Nile virus, Tick-borne encephalitis virus, Japanese encephalitis virus, and Dengue virus 2[]. Flaviviruses consist of three structural proteins: the core nucleocapsid protein C (), and the envelope glycoproteins M () and E. Glycoprotein E is a class II viral fusion protein that mediates both receptor binding and fusion. Class II viral fusion proteins are found in flaviviruses and alphaviruses, and are structurally distinct from class I fusion proteins from influenza-type viruses and retroviruses. Glycoprotein E is comprised of three domains: domain I (dimerisation domain) is an 8-stranded beta barrel, domain II (central domain) is an elongated domain composed of twelve beta strands and two alpha helices, and domain III (immunoglobulin-like domain) is an IgC-like module with ten beta strands. This entry represents the Ig-like domain III, which contains a putative receptor-binding loop []. | Short Name: | Flavovir_Ig-like |
| DB identifier | Type | Name |
|---|---|---|
| IPR000336 | Domain | Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain |
