Protein Domain : IPR001033

Type:  Family Name:  Alpha-catenin
Description:  Catenins associate with the cytoplasmic domains of a variety of cadherins [] producing a complex that links to the actin filament network. This association appears to be indispensable for tight cell-cell adhesion. Dysfunction of the complex causes dissociation of cancer cells from primary tumours, possibly contributing to cancer invasion and metastasis [].Three different forms of catenin (designated alpha, beta and gamma) comprise the cytoplasmic domain of the cadherin cell-cell adhesion complex []. Alpha-catenins are evolutionarily related to vinculin. In vertebrates two isoforms of alpha-catenin coexist, alphaE- and alphaN- catenins (or Catenin alpha-1 and -2), encoded by two separate genes []. AlphaE-catenin forms a cadherin/beta-catenin/alphaE-catenin complex that can tether the tripartite adhesion complex and regulate actin dynamics []. Short Name:  Alpha_catenin
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4 Child Features

DB identifier Type Name
IPR030044 Family Alpha T-catenin
IPR030045 Family Alpha-catulin 1
IPR030046 Family Alpha N-catenin
IPR030047 Family Alpha E-catenin

1 Contains

DB identifier Type Name
IPR000633 Conserved_site Vinculin, conserved site

1 Cross References

Identifier
PR00805

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0045296 IPR001033
GO:0051015 IPR001033
GO:0007155 IPR001033

3 Ontology Annotations

GO Term Gene Name
GO:0045296 IPR001033
GO:0051015 IPR001033
GO:0007155 IPR001033

1 Parent Features

DB identifier Type Name
IPR006077 Family Vinculin/alpha-catenin

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1924379
            8323564
            7945318
            23739176