Protein Domain : IPR020890

Type:  Family Name:  Transcription regulator HTH, HdfR
Description:  Numerous bacterial transcription regulatory proteins bind DNA via a helix-turn-helix (HTH) motif. These proteins are very diverse, but for convenience may be grouped into subfamilies on the basis of sequence similarity. One such family, the lysR family, groups together a range of proteins, including ampR, catM, catR, cynR, cysB, gltC, iciA, ilvY, irgB, lysR, metR, mkaC, mleR, nahR, nhaR, nodD, nolR, oxyR, pssR, rbcR, syrM, tcbR, tfdS and trpI [, , , , ]. The majority of these proteins appear to be transcription activatorsand most are known to negatively regulate their own expression. All possess a potential HTH DNA-binding motif towards their N-termini.The hdfR gene encodes a LysR family protein. HdfR is able to bind to the flhDC promoter, indicating that HdfR is a transcriptional regulator for the flagellar master operon. Furthermore, the expression of the hdfR gene was shown to be negatively regulated by H-NS []. Short Name:  Tscrpt_reg_HTH_HdfR

0 Child Features

3 Contains

DB identifier Type Name
IPR011991 Domain Winged helix-turn-helix DNA-binding domain
IPR005119 Domain LysR, substrate-binding
IPR000847 Domain Transcription regulator HTH, LysR

1 Cross References

Identifier
MF_01233

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003677 IPR020890
GO:0003700 IPR020890
GO:0045892 IPR020890

3 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR020890
GO:0003700 IPR020890
GO:0045892 IPR020890

0 Parent Features

0 Proteins

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1907267
            1592818
            1840615
            3413113
            2034653
            10913108