| Type: | Family | Name: | Putative arginyl-tRNA--protein transferase, prokaryotic |
| Description: | Arginine-tRNA-protein transferase catalyses the post-translational conjugation of arginine to the N terminus of a protein. In eukaryotes, this functions as part of the N-end rule pathway of protein degradation by conjugating a destabilising amino acid to the N-terminal aspartate or glutamate of a protein, targeting the protein for ubiquitin-dependent proteolysis []. In Saccharomyces cerevisiae, Cys20, 23, 94 and/or 95 are thought to be important for activity []. Of these, only Cys 94 appears to be completely conserved in this family. This group represents a predicted arginyl-tRNA-protein transferase, prokaryotic type found only in bacteria. It requires mercaptoethanol and an univalent cation. Peptides and proteins containing an N-terminal glutamate, aspartate or cysteine residue can act as acceptors. | Short Name: | Arg-tRNA-P_Trfase_prd_prok |
