| Type: | Family | Name: | Ras-GEF domain-containing family member 1B |
| Description: | RGF1B is a guanine nucleotide exchange factor for Rap2, a member of the Rap subfamily of Ras-like G-proteins []. It interacts with the coiled-coil domain-containing protein-124 (Ccdc124), which is a centrosomal and midbody protein involved in cytokinesis []. In macrophages the expression of RasGEF1B is mostly induced by TLR3 and TLR4, and this induction may trigger Ras-like proteins' activity and regulate specific biological activities []. | Short Name: | RGF1B |
