Protein Domain : IPR001321

Type:  Family Name:  Hypoxia-inducible factor-1 alpha
Description:  Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Specifically, they respond to decreases in oxygen, mediating the effects of hypoxia []. HIFs are heterodimers, composed of an alpha and a beta subunit. At least 3 different alpha subunits are known to exist, termed HIF-1, -2 and -3 alpha. Beta subunits, meanwhile, are constitutively-expressedaryl hydrocarbon receptor nuclear translocators (ARNTs).In addition to their role in hypoxia, HIFs have been shown to be involved in a range of processes, including angiogenesis, metal transport, mitochondrial function and cell growth [].This entry represents the HIF-1 alpha subunit. Short Name:  HIF-1_alpha
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0 Child Features

0 Contains

1 Cross References

Identifier
PR01080

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0003700 IPR001321
GO:0006355 IPR001321
GO:0005634 IPR001321

3 Ontology Annotations

GO Term Gene Name
GO:0003700 IPR001321
GO:0006355 IPR001321
GO:0005634 IPR001321

1 Parent Features

DB identifier Type Name
IPR021537 Family Hypoxia-inducible factor, alpha subunit

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            18410568
            19756382