Protein Domain : IPR021537

Type:  Family Name:  Hypoxia-inducible factor, alpha subunit
Description:  Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Specifically, they respond to decreases in oxygen, mediating the effects of hypoxia []. HIFs are heterodimers, composed of an alpha and a beta subunit. At least 3 different alpha subunits are known to exist, termed HIF-1, -2 and -3 alpha. Beta subunits, meanwhile, are constitutively-expressed aryl hydrocarbon receptor nuclear translocators (ARNTs).In addition to their role in hypoxia, HIFs have been shown to be involved in a range of processes, including angiogenesis, metal transport, mitochondrial function and cell growth [].This entry represents HIF alpha subunits. Short Name:  HIF_alpha_subunit

1 Child Features

DB identifier Type Name
IPR001321 Family Hypoxia-inducible factor-1 alpha

0 Contains

1 Cross References

Identifier
PF11413

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            18410568
            19756382