GO Term : GO:0016236 macroautophagy GO

Namespace:  biological_process Obsolete:  false
description  The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded.

0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

1 Ontology Annotations

GO Term Gene Name
GO:0016236 IPR023261

15 Parents

Identifier Name Description
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0006914 autophagy The process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances.
GO:0000045 autophagosome assembly The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.
GO:0007033 vacuole organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.
GO:0016043 cellular component organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0006996 organelle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0071840 cellular component organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0044248 cellular catabolic process The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
GO:0009056 catabolic process The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
GO:0070925 organelle assembly The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0022607 cellular component assembly The aggregation, arrangement and bonding together of a cellular component.
GO:0016236 macroautophagy The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded.

80 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
part of GO:0016236 GO:0000045
is_a GO:0016236 GO:0000423
is_a GO:0016236 GO:0000425
has_part GO:0000045 GO:0016236
has_part GO:0000045 GO:0016236
is_a GO:0006914 GO:0016236
is_a GO:0006914 GO:0016236
has_part GO:0006996 GO:0016236
has_part GO:0009987 GO:0016236
is_a GO:0009987 GO:0016236
has_part GO:0071840 GO:0016236
is_a GO:0008150 GO:0016236
has_part GO:0016043 GO:0016236
has_part GO:0022607 GO:0016236
has_part GO:0070925 GO:0016236
has_part GO:0044248 GO:0016236
has_part GO:0044237 GO:0016236
has_part GO:0009056 GO:0016236
has_part GO:0007033 GO:0016236
has_part GO:0008152 GO:0016236
has_part GO:0008150 GO:0016236
positively regulates GO:0016236 GO:0016239
positively regulates GO:0016236 GO:0016239
regulates GO:0016236 GO:0016239
part of GO:0016236 GO:0016240
regulates GO:0016236 GO:0016241
regulates GO:0016236 GO:0016241
negatively regulates GO:0016236 GO:0016242
negatively regulates GO:0016236 GO:0016242
regulates GO:0016236 GO:0016242

4 Synonyms

Name Type
non-specific autophagy synonym
autophagy in response to cellular starvation synonym
GO:0034262 alt_id
starvation-induced autophagy synonym