GO Term : GO:0061505 DNA topoisomerase II activity GO

Namespace:  molecular_function Obsolete:  false
description  Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; changes the linking number in multiples of 2.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

12 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0003677 DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0003676 nucleic acid binding Interacting selectively and non-covalently with any nucleic acid.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0016853 isomerase activity Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
GO:0003916 DNA topoisomerase activity Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:1901363 heterocyclic compound binding Interacting selectively and non-covalently with heterocyclic compound.
GO:0097159 organic cyclic compound binding Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.
GO:0061505 DNA topoisomerase II activity Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; changes the linking number in multiples of 2.

24 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0061505 GO:0003918
negatively regulates GO:0061505 GO:0008657
regulates GO:0061505 GO:0008657
is_a GO:0003916 GO:0061505
part of GO:0008152 GO:0061505
is_a GO:0016853 GO:0061505
has_part GO:1901363 GO:0061505
has_part GO:0097159 GO:0061505
is_a GO:0003674 GO:0061505
part of GO:0008150 GO:0061505
has_part GO:0003674 GO:0061505
has_part GO:0005488 GO:0061505
is_a GO:0003824 GO:0061505
has_part GO:0003676 GO:0061505
has_part GO:0003677 GO:0061505
is_a GO:0061505 GO:0061506
regulates GO:0061505 GO:0072586
positively regulates GO:0061505 GO:0072587
regulates GO:0061505 GO:0072587
regulates GO:0061505 GO:2000371
negatively regulates GO:0061505 GO:2000372
regulates GO:0061505 GO:2000372
regulates GO:0061505 GO:2000373
positively regulates GO:0061505 GO:2000373

0 Synonyms