GO Term : GO:0005923 bicellular tight junction GO
Namespace:  cellular_component Obsolete:  false
description  An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
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0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

25 Ontology Annotations

GO Term Gene Name
GO:0005923 IPR002958
GO:0005923 IPR003548
GO:0005923 IPR003549
GO:0005923 IPR003550
GO:0005923 IPR003551
GO:0005923 IPR003552
GO:0005923 IPR003553
GO:0005923 IPR003554
GO:0005923 IPR003555
GO:0005923 IPR003556
GO:0005923 IPR003925
GO:0005923 IPR003926
GO:0005923 IPR003927
GO:0005923 IPR003928
GO:0005923 IPR005411
GO:0005923 IPR005417
GO:0005923 IPR005418
GO:0005923 IPR005419
GO:0005923 IPR005420
GO:0005923 IPR006187
GO:0005923 IPR008094
GO:0005923 IPR017974
GO:0005923 IPR028179
GO:0005923 IPR030033
GO:0005923 IPR030036

6 Parents

Identifier Name Description
GO:0030054 cell junction A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0005911 cell-cell junction A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
GO:0043296 apical junction complex A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.
GO:0070160 occluding junction A cell-cell junction that seals cells together in an epithelium in a way that prevents even small molecules from leaking from one side of the sheet to the other.
GO:0005923 bicellular tight junction An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.

9 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
is_a GO:0070160 GO:0005923
part of GO:0043296 GO:0005923
part of GO:0005575 GO:0005923
is_a GO:0005575 GO:0005923
is_a GO:0030054 GO:0005923
part of GO:0005911 GO:0005923
is_a GO:0005911 GO:0005923
part of GO:0030054 GO:0005923
is_a GO:0005923 GO:0044647

1 Synonyms

Name Type
zonula occludens synonym