GO Term : GO:0030294 receptor signaling protein tyrosine kinase inhibitor activity GO
Namespace:  molecular_function Obsolete:  false
description  Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase.
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0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

99 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0005515 protein binding Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
GO:0004672 protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
GO:0004713 protein tyrosine kinase activity Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
GO:0006468 protein phosphorylation The process of introducing a phosphate group on to a protein.
GO:0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0007165 signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
GO:0016772 transferase activity, transferring phosphorus-containing groups Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0006796 phosphate-containing compound metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.
GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances.
GO:0019901 protein kinase binding Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
GO:0004871 signal transducer activity Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
GO:0016301 kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
GO:0016773 phosphotransferase activity, alcohol group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).
GO:0035556 intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
GO:0016740 transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
GO:0004857 enzyme inhibitor activity Binds to and stops, prevents or reduces the activity of an enzyme.
GO:0030234 enzyme regulator activity Binds to and modulates the activity of an enzyme.
GO:0019887 protein kinase regulator activity Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein.
GO:0006464 cellular protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
GO:0071704 organic substance metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
GO:0043412 macromolecule modification The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties.
GO:0044238 primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0001932 regulation of protein phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
GO:0050790 regulation of catalytic activity Any process that modulates the activity of an enzyme.
GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme.
GO:0045859 regulation of protein kinase activity Any process that modulates the frequency, rate or extent of protein kinase activity.

128 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
is_a GO:0030292 GO:0030294
negatively regulates GO:0004716 GO:0030294
part of GO:0001932 GO:0030294
part of GO:0050789 GO:0030294
part of GO:0001933 GO:0030294
negatively regulates GO:0007154 GO:0030294
part of GO:0019222 GO:0030294
negatively regulates GO:0006464 GO:0030294
regulates GO:0003824 GO:0030294
negatively regulates GO:0044699 GO:0030294
negatively regulates GO:0006468 GO:0030294
part of GO:0019220 GO:0030294
negatively regulates GO:0051716 GO:0030294
negatively regulates GO:0016301 GO:0030294
negatively regulates GO:0019538 GO:0030294
part of GO:0051248 GO:0030294
regulates GO:0036211 GO:0030294
part of GO:0048519 GO:0030294
part of GO:0050794 GO:0030294
regulates GO:0003674 GO:0030294
part of GO:0051246 GO:0030294
negatively regulates GO:0004672 GO:0030294
negatively regulates GO:0023014 GO:0030294
negatively regulates GO:0043412 GO:0030294
part of GO:0050790 GO:0030294
is_a GO:0003674 GO:0030294
is_a GO:0019210 GO:0030294
regulates GO:0044237 GO:0030294
regulates GO:0044238 GO:0030294
negatively regulates GO:0004713 GO:0030294

1 Synonyms

Name Type
receptor signalling protein tyrosine kinase inhibitor activity synonym