GO Term : GO:0030845 phospholipase C-inhibiting G-protein coupled receptor signaling pathway GO
Namespace:  biological_process Obsolete:  false
description  A G-protein coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG).
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0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

30 Parents

Identifier Name Description
GO:0007165 signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0007186 G-protein coupled receptor signaling pathway A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
GO:0050790 regulation of catalytic activity Any process that modulates the activity of an enzyme.
GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme.
GO:0051716 cellular response to stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0050896 response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0050794 regulation of cellular process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0019222 regulation of metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0065009 regulation of molecular function Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:0009892 negative regulation of metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0048519 negative regulation of biological process Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0023052 signaling The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
GO:0044700 single organism signaling A signaling process occurring within a single organism.
GO:0044092 negative regulation of molecular function Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:0051336 regulation of hydrolase activity Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
GO:0051346 negative regulation of hydrolase activity Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.
GO:1900274 regulation of phospholipase C activity Any process that modulates the frequency, rate or extent of phospholipase C activity.
GO:0010517 regulation of phospholipase activity Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.
GO:0060191 regulation of lipase activity Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.
GO:0060192 negative regulation of lipase activity Any process that decreases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.
GO:0010519 negative regulation of phospholipase activity Any process that decreases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.
GO:1900275 negative regulation of phospholipase C activity Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C activity.
GO:0030845 phospholipase C-inhibiting G-protein coupled receptor signaling pathway A G-protein coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG).

35 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
has_part GO:1900275 GO:0030845
is_a GO:0007186 GO:0030845
part of GO:0009987 GO:0030845
has_part GO:0048519 GO:0030845
part of GO:0023052 GO:0030845
has_part GO:0009892 GO:0030845
has_part GO:0050790 GO:0030845
part of GO:0044699 GO:0030845
has_part GO:0010519 GO:0030845
has_part GO:0010517 GO:0030845
is_a GO:0065007 GO:0030845
has_part GO:1900274 GO:0030845
part of GO:0050896 GO:0030845
has_part GO:0051346 GO:0030845
has_part GO:0060191 GO:0030845
has_part GO:0060192 GO:0030845
has_part GO:0008150 GO:0030845
has_part GO:0019222 GO:0030845
is_a GO:0008150 GO:0030845
has_part GO:0065009 GO:0030845
has_part GO:0065007 GO:0030845
regulates GO:0008150 GO:0030845
is_a GO:0050789 GO:0030845
part of GO:0007154 GO:0030845
part of GO:0044763 GO:0030845
part of GO:0044700 GO:0030845
is_a GO:0007165 GO:0030845
regulates GO:0009987 GO:0030845
part of GO:0051716 GO:0030845
part of GO:0008150 GO:0030845

6 Synonyms

Name Type
G-protein-coupled inhibitory pathway of phospholipase C synonym
GPCR signaling pathway coupled to inhibition of phospholipase C activity synonym
GPCR signaling pathway via inhibition of PLC synonym
inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway synonym
phospholipase C inhibition synonym
PLC-inhibiting GPCR signaling pathway synonym