GO Term : GO:0032933 SREBP signaling pathway GO
Namespace:  biological_process Obsolete:  false
description  A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
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0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

1 Ontology Annotations

GO Term Gene Name
GO:0032933 IPR030225

80 Parents

Identifier Name Description
GO:0006355 regulation of transcription, DNA-templated Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:0006357 regulation of transcription from RNA polymerase II promoter Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
GO:0007165 signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances.
GO:0006950 response to stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
GO:0006351 transcription, DNA-templated The cellular synthesis of RNA on a template of DNA.
GO:0006807 nitrogen compound metabolic process The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
GO:0006139 nucleobase-containing compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
GO:0010468 regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
GO:0071704 organic substance metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
GO:0051252 regulation of RNA metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
GO:0044238 primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0006725 cellular aromatic compound metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
GO:0006366 transcription from RNA polymerase II promoter The synthesis of RNA from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
GO:0016070 RNA metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
GO:0044249 cellular biosynthetic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
GO:0009059 macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GO:0045893 positive regulation of transcription, DNA-templated Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
GO:0051716 cellular response to stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
GO:0044260 cellular macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0045944 positive regulation of transcription from RNA polymerase II promoter Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0050896 response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
GO:0090304 nucleic acid metabolic process Any cellular metabolic process involving nucleic acids.

153 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
is_a GO:0006984 GO:0032933
is_a GO:0071501 GO:0032933
is_a GO:0045944 GO:0032933
positively regulates GO:0009058 GO:0032933
part of GO:0044763 GO:0032933
is_a GO:0008150 GO:0032933
positively regulates GO:0009059 GO:0032933
is_a GO:0031328 GO:0032933
regulates GO:0006351 GO:0032933
is_a GO:0009889 GO:0032933
regulates GO:0046483 GO:0032933
is_a GO:0010628 GO:0032933
regulates GO:0009987 GO:0032933
part of GO:0008150 GO:0032933
positively regulates GO:1901362 GO:0032933
positively regulates GO:0046483 GO:0032933
is_a GO:2001141 GO:0032933
positively regulates GO:1901360 GO:0032933
regulates GO:0019438 GO:0032933
regulates GO:0010467 GO:0032933
regulates GO:0006366 GO:0032933
is_a GO:0010468 GO:0032933
positively regulates GO:0097659 GO:0032933
regulates GO:0034654 GO:0032933
positively regulates GO:0019438 GO:0032933
is_a GO:0051171 GO:0032933
positively regulates GO:0010467 GO:0032933
positively regulates GO:0034654 GO:0032933
part of GO:0050896 GO:0032933
regulates GO:0006807 GO:0032933

23 Synonyms

Name Type
SREBP target gene transcriptional activation synonym
SREBP-mediated signaling pathway synonym
SREBP-mediated signalling pathway synonym
sterol depletion response, SREBP target gene transcriptional activation synonym
sterol regulatory element binding protein target gene transcriptional activation synonym
sterol response element binding protein signaling pathway synonym
stimulation of sterol regulatory element binding protein target gene transcription synonym
up regulation of sterol regulatory element binding protein target gene transcription synonym
up-regulation of sterol regulatory element binding protein target gene transcription synonym
upregulation of sterol regulatory element binding protein target gene transcription synonym
GO:0006994 alt_id
GO:0030967 alt_id
GO:0035104 alt_id
activation of sterol regulatory element binding protein target gene transcription synonym
endoplasmic reticulum to nucleus sterol response pathway synonym
endoplasmic reticulum-nuclear sterol response pathway synonym
ER to nucleus sterol response pathway synonym
ER-nuclear sterol response pathway synonym
positive regulation of sterol regulatory element binding protein target gene transcription synonym
positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response synonym
positive regulation of transcription via sterol regulatory element binding synonym
positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway synonym
SREBP signalling synonym