GO Term : GO:0033596 TSC1-TSC2 complex GO

Namespace:  cellular_component Obsolete:  false
description  A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.

0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

1 Ontology Annotations

GO Term Gene Name
GO:0033596 IPR003913

12 Parents

Identifier Name Description
GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0043234 protein complex A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0005829 cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0044445 cytosolic part Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components.
GO:0044464 cell part Any constituent part of a cell, the basic structural and functional unit of all organisms.
GO:0044444 cytoplasmic part Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0044424 intracellular part Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0032991 macromolecular complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0005623 cell The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
GO:0033596 TSC1-TSC2 complex A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.

15 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0044445 GO:0033596
is_a GO:0043234 GO:0033596
part of GO:0005829 GO:0033596
part of GO:0044464 GO:0033596
part of GO:0044444 GO:0033596
part of GO:0044424 GO:0033596
is_a GO:0005575 GO:0033596
is_a GO:0044424 GO:0033596
part of GO:0005623 GO:0033596
part of GO:0005622 GO:0033596
is_a GO:0044464 GO:0033596
part of GO:0005737 GO:0033596
is_a GO:0044444 GO:0033596
part of GO:0005575 GO:0033596
is_a GO:0032991 GO:0033596

2 Synonyms

Name Type
tuberin-hamartin complex synonym
tuberous sclerosis complex synonym