GO Term : GO:0038005 peptide bond cleavage involved in epidermal growth factor receptor ligand maturation GO

Namespace:  biological_process Obsolete:  false
description  The hydrolysis of a peptide bond or bonds within a ligand for the epidermal growth factor receptor, as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein. In Drosophila for example, in the Golgi apparatus of the signal producing cell, Spitz is cleaved within its transmembrane domain to release a functional soluble extracellular fragment.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

36 Parents

Identifier Name Description
GO:0006508 proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
GO:0071704 organic substance metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
GO:0009966 regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction.
GO:0016485 protein processing Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.
GO:0044238 primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0044710 single-organism metabolic process A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves a single organism.
GO:0043170 macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0050794 regulation of cellular process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0010467 gene expression The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
GO:0023051 regulation of signaling Any process that modulates the frequency, rate or extent of a signaling process.
GO:0009967 positive regulation of signal transduction Any process that activates or increases the frequency, rate or extent of signal transduction.
GO:0023056 positive regulation of signaling Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.
GO:0048583 regulation of response to stimulus Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
GO:0048584 positive regulation of response to stimulus Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
GO:0048522 positive regulation of cellular process Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0048518 positive regulation of biological process Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0010647 positive regulation of cell communication Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GO:0010646 regulation of cell communication Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GO:0051604 protein maturation Any process leading to the attainment of the full functional capacity of a protein.
GO:0033619 membrane protein proteolysis The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.
GO:0006509 membrane protein ectodomain proteolysis The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain).
GO:1901184 regulation of ERBB signaling pathway Any process that modulates the frequency, rate or extent of ERBB signaling pathway.

51 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
part of GO:0038004 GO:0038005
has_part GO:0006509 GO:0038005
part of GO:0038004 GO:0038005
is_a GO:0016485 GO:0038005
is_a GO:0016485 GO:0038005
part of GO:0048518 GO:0038005
part of GO:0044238 GO:0038005
part of GO:0044710 GO:0038005
has_part GO:0043170 GO:0038005
part of GO:0044699 GO:0038005
part of GO:0042058 GO:0038005
part of GO:0045742 GO:0038005
has_part GO:0006508 GO:0038005
is_a GO:0044238 GO:0038005
part of GO:0009967 GO:0038005
is_a GO:0071704 GO:0038005
part of GO:0050794 GO:0038005
part of GO:1901184 GO:0038005
has_part GO:0033619 GO:0038005
part of GO:0043170 GO:0038005
is_a GO:0019538 GO:0038005
part of GO:0048584 GO:0038005
is_a GO:0006508 GO:0038005
part of GO:0051604 GO:0038005
part of GO:0035638 GO:0038005
part of GO:1901186 GO:0038005
part of GO:0048583 GO:0038005
part of GO:0044763 GO:0038005
part of GO:0048522 GO:0038005
part of GO:0065007 GO:0038005

4 Synonyms

Name Type
EGFR ligand processing synonym
EGFR ligand maturation by peptide bond cleavage synonym
peptide bond cleavage involved in EGFR ligand maturation synonym
epidermal growth factor receptor ligand processing synonym