GO Term : GO:0039546 suppression by virus of host MAVS activity by MAVS proteolysis GO
Namespace:  biological_process Obsolete:  false
description  The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host MAVS (mitochondrial inhibitor of viral signaling) protein by cleavage of peptide bonds, thereby inhibiting the host innate immune response. For example, MAVS harbors a C-terminal transmembrane domain that targets it to the mitochondrial outer membrane; cleavage within this domain removes MAVS from the membrane, thus preventing it from signaling.
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0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

154 Parents

Identifier Name Description
GO:0006508 proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
GO:0007165 signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
GO:0009607 response to biotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
GO:0006950 response to stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
GO:0035556 intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
GO:0071704 organic substance metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
GO:0009966 regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction.
GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
GO:0044238 primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0031347 regulation of defense response Any process that modulates the frequency, rate or extent of a defense response.
GO:0051716 cellular response to stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
GO:0016032 viral process A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.
GO:0030683 evasion or tolerance by virus of host immune response Any process, either active or passive, by which a virus avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GO:0045087 innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0051607 defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
GO:0019048 modulation by virus of host morphology or physiology The process in which a virus effects a change in the structure or processes of its host organism.
GO:0002682 regulation of immune system process Any process that modulates the frequency, rate, or extent of an immune system process.
GO:0031348 negative regulation of defense response Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0050896 response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
GO:0043170 macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.

231 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
is_a GO:0035897 GO:0039546
is_a GO:0039545 GO:0039546
negatively regulates GO:0009615 GO:0039546
is_a GO:0044033 GO:0039546
negatively regulates GO:0051716 GO:0039546
is_a GO:0051805 GO:0039546
is_a GO:0048519 GO:0039546
is_a GO:0043170 GO:0039546
regulates GO:0002218 GO:0039546
regulates GO:0050776 GO:0039546
regulates GO:0050778 GO:0039546
is_a GO:0052572 GO:0039546
regulates GO:0050896 GO:0039546
is_a GO:0080134 GO:0039546
negatively regulates GO:0009605 GO:0039546
regulates GO:0048584 GO:0039546
regulates GO:0048583 GO:0039546
regulates GO:0003674 GO:0039546
regulates GO:0002221 GO:0039546
regulates GO:0001817 GO:0039546
negatively regulates GO:0051707 GO:0039546
is_a GO:0075109 GO:0039546
negatively regulates GO:0051704 GO:0039546
negatively regulates GO:0009607 GO:0039546
regulates GO:0050789 GO:0039546
is_a GO:0052205 GO:0039546
is_a GO:0052204 GO:0039546
is_a GO:0019054 GO:0039546
is_a GO:0052562 GO:0039546
is_a GO:0052561 GO:0039546

1 Synonyms

Name Type
viral protease cleavage of MAVS synonym