GO Term : GO:0039583 suppression by virus of host PKR activity by positive regulation of PKR catabolic process GO
Namespace:  biological_process Obsolete:  false
description  Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the degradation of PKR via the proteosome. For example, the Rift Valley fever virus (RVFV) NSs protein induces the down-regulation of PKR by degradation through proteasomes.
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0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

200 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0004672 protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
GO:0006468 protein phosphorylation The process of introducing a phosphate group on to a protein.
GO:0006508 proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
GO:0030163 protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
GO:0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
GO:0016772 transferase activity, transferring phosphorus-containing groups Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0006952 defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
GO:0009607 response to biotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
GO:0006796 phosphate-containing compound metabolic process The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.
GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances.
GO:0051603 proteolysis involved in cellular protein catabolic process The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.
GO:0006950 response to stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
GO:0016301 kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
GO:0016773 phosphotransferase activity, alcohol group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).
GO:0006511 ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
GO:0016740 transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
GO:0006464 cellular protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
GO:0071704 organic substance metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
GO:0006955 immune response Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
GO:0043412 macromolecule modification The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties.
GO:0042176 regulation of protein catabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
GO:0044238 primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0001932 regulation of protein phosphorylation Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
GO:0050790 regulation of catalytic activity Any process that modulates the activity of an enzyme.
GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme.
GO:0031347 regulation of defense response Any process that modulates the frequency, rate or extent of a defense response.

274 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
is_a GO:0032436 GO:0039583
is_a GO:0039580 GO:0039583
negatively regulates GO:0043170 GO:0039583
negatively regulates GO:0044260 GO:0039583
negatively regulates GO:0044267 GO:0039583
is_a GO:0002832 GO:0039583
regulates GO:0009607 GO:0039583
is_a GO:0002831 GO:0039583
is_a GO:0044359 GO:0039583
regulates GO:0009605 GO:0039583
regulates GO:0009056 GO:0039583
regulates GO:0009057 GO:0039583
regulates GO:0006464 GO:0039583
regulates GO:0043632 GO:0039583
regulates GO:0051707 GO:0039583
is_a GO:0031399 GO:0039583
regulates GO:0051704 GO:0039583
positively regulates GO:0043632 GO:0039583
positively regulates GO:0019538 GO:0039583
negatively regulates GO:0003824 GO:0039583
regulates GO:0009615 GO:0039583
regulates GO:0006468 GO:0039583
is_a GO:1901800 GO:0039583
is_a GO:0042176 GO:0039583
regulates GO:0019538 GO:0039583
is_a GO:0010563 GO:0039583
part of GO:0008150 GO:0039583
is_a GO:0052553 GO:0039583
is_a GO:0052552 GO:0039583
positively regulates GO:0010498 GO:0039583

2 Synonyms

Name Type
promotion by virus of proteosome-dependent PKR degradation synonym
downregulation of PKR by degradation through proteosome synonym