GO Term : GO:0042799 histone methyltransferase activity (H4-K20 specific) GO

Namespace:  molecular_function Obsolete:  false
description  Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein.

0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

2 Ontology Annotations

GO Term Gene Name
GO:0042799 IPR025783
GO:0042799 IPR025790

49 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0008168 methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances.
GO:0018024 histone-lysine N-methyltransferase activity Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
GO:0019538 protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
GO:0051276 chromosome organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
GO:0016740 transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
GO:0016568 chromatin modification The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure.
GO:0006464 cellular protein modification process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
GO:0071704 organic substance metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon.
GO:0006479 protein methylation The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom.
GO:0016570 histone modification The covalent alteration of one or more amino acid residues within a histone protein.
GO:0043412 macromolecule modification The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties.
GO:0032259 methylation The process in which a methyl group is covalently attached to a molecule.
GO:0044238 primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0008276 protein methyltransferase activity Catalysis of the transfer of a methyl group (CH3-) to a protein.
GO:0008170 N-methyltransferase activity Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule.
GO:0016571 histone methylation The modification of histones by addition of methyl groups.
GO:0034968 histone lysine methylation The modification of a histone by addition of one or more methyl groups to a lysine residue.
GO:0044260 cellular macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
GO:0016279 protein-lysine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.
GO:0018193 peptidyl-amino acid modification The alteration of an amino acid residue in a peptide.
GO:0016043 cellular component organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
GO:0044267 cellular protein metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0006325 chromatin organization Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
GO:0006996 organelle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.

48 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0018024 GO:0042799
part of GO:0034770 GO:0042799
part of GO:0043412 GO:0042799
part of GO:0071704 GO:0042799
is_a GO:0008757 GO:0042799
part of GO:0044763 GO:0042799
part of GO:0016570 GO:0042799
part of GO:0008150 GO:0042799
part of GO:0044267 GO:0042799
part of GO:0008152 GO:0042799
part of GO:0016571 GO:0042799
part of GO:0071840 GO:0042799
part of GO:0044260 GO:0042799
part of GO:0043170 GO:0042799
is_a GO:0003824 GO:0042799
is_a GO:0016740 GO:0042799
part of GO:0034968 GO:0042799
part of GO:0006464 GO:0042799
is_a GO:0008170 GO:0042799
is_a GO:0016741 GO:0042799
part of GO:0051276 GO:0042799
is_a GO:0008276 GO:0042799
is_a GO:0042054 GO:0042799
part of GO:0043933 GO:0042799
part of GO:0043414 GO:0042799
part of GO:0006325 GO:0042799
part of GO:0044238 GO:0042799
part of GO:0044237 GO:0042799
part of GO:0044699 GO:0042799
part of GO:0044710 GO:0042799

3 Synonyms

Name Type
histone lysine N-methyltransferase activity (H4-K20 specific) synonym
histone H4 lysine 20-specific methyltransferase activity synonym
histone methylase activity (H4-K20 specific) synonym