GO Term : GO:0043490 malate-aspartate shuttle GO

Namespace:  biological_process Obsolete:  false
description  The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle.

0 Cross References

1 Data Sets

Name URL
InterPro domain GO annotations  

1 Ontology

Name
GO

1 Ontology Annotations

GO Term Gene Name
GO:0043490 IPR029658

28 Parents

Identifier Name Description
GO:0055114 oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
GO:0006810 transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0044237 cellular metabolic process The chemical reactions and pathways by which individual cells transform chemical substances.
GO:0022900 electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
GO:0022904 respiratory electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.
GO:0006839 mitochondrial transport Transport of substances into, out of or within a mitochondrion.
GO:0046907 intracellular transport The directed movement of substances within a cell.
GO:0006091 generation of precursor metabolites and energy The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0051641 cellular localization A localization process that takes place at the cellular level; as a result of a cellular localization process, a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.
GO:0051179 localization Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to or maintained in a specific location.
GO:1902578 single-organism localization A localization which involves only one organism.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0051234 establishment of localization The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
GO:0044765 single-organism transport The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving a single organism.
GO:0044710 single-organism metabolic process A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves a single organism.
GO:0044464 cell part Any constituent part of a cell, the basic structural and functional unit of all organisms.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0005623 cell The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
GO:1902582 single-organism intracellular transport An intracellular transport which involves only one organism.
GO:0051649 establishment of localization in cell The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.
GO:0015980 energy derivation by oxidation of organic compounds The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released.
GO:0045333 cellular respiration The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).
GO:0043490 malate-aspartate shuttle The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle.

30 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0006839 GO:0043490
part of GO:0022904 GO:0043490
part of GO:0055114 GO:0043490
is_a GO:0044765 GO:0043490
is_a GO:1902582 GO:0043490
is_a GO:0008150 GO:0043490
part of GO:0045333 GO:0043490
part of GO:0044237 GO:0043490
part of GO:0044699 GO:0043490
part of GO:0044710 GO:0043490
part of GO:0044763 GO:0043490
is_a GO:1902578 GO:0043490
occurs in GO:0005575 GO:0043490
part of GO:0022900 GO:0043490
is_a GO:0051234 GO:0043490
is_a GO:0051179 GO:0043490
is_a GO:0046907 GO:0043490
part of GO:0015980 GO:0043490
part of GO:0051641 GO:0043490
part of GO:0009987 GO:0043490
is_a GO:0044699 GO:0043490
part of GO:0008152 GO:0043490
occurs in GO:0044464 GO:0043490
is_a GO:0051649 GO:0043490
occurs in GO:0005623 GO:0043490
occurs in GO:0005622 GO:0043490
part of GO:0006091 GO:0043490
part of GO:0008150 GO:0043490
is_a GO:0006810 GO:0043490
part of GO:0051179 GO:0043490

3 Synonyms

Name Type
malate aspartate shuttle synonym
malate/aspartate shuttle synonym
malate:aspartate shuttle synonym