GO Term : GO:0048788 cytoskeleton of presynaptic active zone GO

Namespace:  cellular_component Obsolete:  false
description  The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

24 Parents

Identifier Name Description
GO:0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0005622 intracellular The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0005856 cytoskeleton Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
GO:0005938 cell cortex The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
GO:0048786 presynaptic active zone A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
GO:0044464 cell part Any constituent part of a cell, the basic structural and functional unit of all organisms.
GO:0044444 cytoplasmic part Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0044424 intracellular part Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0005623 cell The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
GO:0043226 organelle Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
GO:0043229 intracellular organelle Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0043228 non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
GO:0043232 intracellular non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
GO:0044448 cell cortex part Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
GO:0071944 cell periphery The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
GO:0030863 cortical cytoskeleton The portion of the cytoskeleton that lies just beneath the plasma membrane.
GO:0045202 synapse The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
GO:0044456 synapse part Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
GO:0097458 neuron part Any constituent part of a neuron, the basic cellular unit of nervous tissue. A typical neuron consists of a cell body (often called the soma), an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
GO:0098793 presynapse The part of a synapse that is part of the presynaptic cell.
GO:0099738 cell cortex region The complete extent of cell cortex that underlies some some region of the plamsma membrane
GO:0048788 cytoskeleton of presynaptic active zone The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites.
GO:0098831 presynaptic active zone cytoplasmic component A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles.

32 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0030863 GO:0048788
is_a GO:0030863 GO:0048788
is_a GO:0044456 GO:0048788
is_a GO:0097458 GO:0048788
part of GO:0098831 GO:0048788
part of GO:0098831 GO:0048788
part of GO:0048786 GO:0048788
is_a GO:0005856 GO:0048788
part of GO:0044456 GO:0048788
part of GO:0045202 GO:0048788
is_a GO:0044424 GO:0048788
part of GO:0005622 GO:0048788
is_a GO:0044448 GO:0048788
is_a GO:0005575 GO:0048788
is_a GO:0044464 GO:0048788
is_a GO:0043232 GO:0048788
is_a GO:0044444 GO:0048788
part of GO:0098793 GO:0048788
part of GO:0005623 GO:0048788
part of GO:0071944 GO:0048788
part of GO:0005938 GO:0048788
part of GO:0097458 GO:0048788
part of GO:0005737 GO:0048788
is_a GO:0043229 GO:0048788
part of GO:0099738 GO:0048788
is_a GO:0043228 GO:0048788
part of GO:0044464 GO:0048788
part of GO:0044444 GO:0048788
part of GO:0044424 GO:0048788
part of GO:0005575 GO:0048788

13 Synonyms

Name Type
active zone cytomatrix synonym
CAZ synonym
pre-synaptic cytoskeletal matrix assembled at active zones synonym
pre-synaptic dense body synonym
pre-synaptic ribbon synonym
presynaptic cytomatrix assembled at active zones synonym
presynaptic cytoskeletal matrix assembled at active zones synonym
presynaptic dense body synonym
presynaptic ribbon synonym
ribbon synonym
synaptic ribbon synonym
T-bar synonym
T-bar ribbon synonym