GO Term : GO:0050901 leukocyte tethering or rolling GO

Namespace:  biological_process Obsolete:  false
description  Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

20 Parents

Identifier Name Description
GO:0048870 cell motility Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
GO:0007155 cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
GO:0006928 movement of cell or subcellular component The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore.
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0044763 single-organism cellular process Any process that is carried out at the cellular level, occurring within a single organism.
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0051179 localization Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to or maintained in a specific location.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0098609 cell-cell adhesion The attachment of one cell to another cell via adhesion molecules.
GO:0022610 biological adhesion The attachment of a cell or organism to a substrate or other organism.
GO:0051674 localization of cell Any process in which a cell is transported to, and/or maintained in, a specific location.
GO:0040011 locomotion Self-propelled movement of a cell or organism from one location to another.
GO:0016477 cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
GO:0002376 immune system process Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
GO:0016337 single organismal cell-cell adhesion The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism.
GO:0098602 single organism cell adhesion The attachment, via cell adhesion molecules, of a cell to either another cell of the same organism, or to an underlying substrate of the same organism such as the extracellular matrix.
GO:0007159 leukocyte cell-cell adhesion The attachment of a leukocyte to another cell via adhesion molecules.
GO:0050900 leukocyte migration The movement of a leukocyte within or between different tissues and organs of the body.
GO:0045123 cellular extravasation The migration of a leukocyte from the blood vessels into the surrounding tissue.
GO:0050901 leukocyte tethering or rolling Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).

29 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
part of GO:0045123 GO:0050901
is_a GO:0007159 GO:0050901
is_a GO:0098602 GO:0050901
part of GO:0008150 GO:0050901
part of GO:0040011 GO:0050901
part of GO:0044699 GO:0050901
is_a GO:0098609 GO:0050901
part of GO:0009987 GO:0050901
part of GO:0002376 GO:0050901
part of GO:0044763 GO:0050901
is_a GO:0008150 GO:0050901
is_a GO:0016337 GO:0050901
part of GO:0006928 GO:0050901
part of GO:0050900 GO:0050901
is_a GO:0007155 GO:0050901
part of GO:0048870 GO:0050901
is_a GO:0044699 GO:0050901
is_a GO:0022610 GO:0050901
part of GO:0051674 GO:0050901
part of GO:0051179 GO:0050901
part of GO:0016477 GO:0050901
regulates GO:0050901 GO:1903236
regulates GO:0050901 GO:1903236
negatively regulates GO:0050901 GO:1903237
negatively regulates GO:0050901 GO:1903237
regulates GO:0050901 GO:1903237
positively regulates GO:0050901 GO:1903238
positively regulates GO:0050901 GO:1903238
regulates GO:0050901 GO:1903238

0 Synonyms