GO Term : GO:0060087 relaxation of vascular smooth muscle GO

Namespace:  biological_process Obsolete:  false
description  A process in which the extent of vascular smooth muscle contraction is reduced. Vascular smooth muscle relaxation is mediated via a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

30 Parents

Identifier Name Description
GO:0006940 regulation of smooth muscle contraction Any process that modulates the frequency, rate or extent of smooth muscle contraction.
GO:0044699 single-organism process A biological process that involves only one organism.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0048519 negative regulation of biological process Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0044707 single-multicellular organism process A biological process occurring within a single, multicellular organism.
GO:0032501 multicellular organismal process Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
GO:0065008 regulation of biological quality Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
GO:0090066 regulation of anatomical structure size Any process that modulates the size of an anatomical structure.
GO:0003008 system process A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
GO:0051239 regulation of multicellular organismal process Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.
GO:0051241 negative regulation of multicellular organismal process Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
GO:0003013 circulatory system process A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.
GO:0008015 blood circulation The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
GO:0003018 vascular process in circulatory system A circulatory process that occurs at the level of the vasculature.
GO:0042311 vasodilation An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure.
GO:0050880 regulation of blood vessel size Any process that modulates the size of blood vessels.
GO:0035150 regulation of tube size Ensuring that a tube is of the correct length and diameter. Tube size must be maintained not only during tube formation, but also throughout development and in some physiological processes.
GO:0044057 regulation of system process Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.
GO:0006936 muscle contraction A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.
GO:0003012 muscle system process A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.
GO:0090257 regulation of muscle system process Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.
GO:0006937 regulation of muscle contraction Any process that modulates the frequency, rate or extent of muscle contraction.
GO:0006939 smooth muscle contraction A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.
GO:0045932 negative regulation of muscle contraction Any process that stops, prevents, or reduces the frequency, rate or extent of muscle contraction.
GO:0090075 relaxation of muscle A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain.
GO:0044557 relaxation of smooth muscle A process in which the extent of smooth muscle contraction is reduced. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.
GO:0045986 negative regulation of smooth muscle contraction Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle contraction.
GO:0060087 relaxation of vascular smooth muscle A process in which the extent of vascular smooth muscle contraction is reduced. Vascular smooth muscle relaxation is mediated via a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity.

49 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
part of GO:0042311 GO:0060087
is_a GO:0045986 GO:0060087
is_a GO:0044557 GO:0060087
negatively regulates GO:0003012 GO:0060087
part of GO:0035150 GO:0060087
part of GO:0090066 GO:0060087
regulates GO:0032501 GO:0060087
is_a GO:0051241 GO:0060087
is_a GO:0008150 GO:0060087
part of GO:0065007 GO:0060087
part of GO:0065008 GO:0060087
part of GO:0008150 GO:0060087
regulates GO:0008150 GO:0060087
is_a GO:0032501 GO:0060087
is_a GO:0044699 GO:0060087
is_a GO:0090075 GO:0060087
part of GO:0003013 GO:0060087
is_a GO:0048519 GO:0060087
is_a GO:0090257 GO:0060087
is_a GO:0044057 GO:0060087
regulates GO:0044699 GO:0060087
is_a GO:0006937 GO:0060087
part of GO:0044707 GO:0060087
part of GO:0003018 GO:0060087
regulates GO:0006939 GO:0060087
negatively regulates GO:0044707 GO:0060087
is_a GO:0003008 GO:0060087
regulates GO:0006936 GO:0060087
part of GO:0050880 GO:0060087
regulates GO:0003008 GO:0060087

1 Synonyms

Name Type
vascular smooth muscle relaxation synonym