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GO:0003824
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catalytic activity
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Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. |
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GO:0005515
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protein binding
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Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). |
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GO:0005488
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binding
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The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. |
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GO:0008152
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metabolic process
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The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. |
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GO:0007049
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cell cycle
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The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
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GO:0007067
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mitotic nuclear division
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A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell. |
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GO:0016874
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ligase activity
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Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. |
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GO:0044237
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cellular metabolic process
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The chemical reactions and pathways by which individual cells transform chemical substances. |
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GO:0051726
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regulation of cell cycle
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Any process that modulates the rate or extent of progression through the cell cycle. |
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GO:0004842
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ubiquitin-protein transferase activity
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Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
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GO:0016567
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protein ubiquitination
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The process in which one or more ubiquitin groups are added to a protein. |
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GO:0019538
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protein metabolic process
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The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. |
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GO:0016740
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transferase activity
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Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. |
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GO:0030234
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enzyme regulator activity
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Binds to and modulates the activity of an enzyme. |
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GO:0030071
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regulation of mitotic metaphase/anaphase transition
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Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle. |
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GO:0006464
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cellular protein modification process
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The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). |
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GO:0071704
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organic substance metabolic process
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The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. |
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GO:0043412
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macromolecule modification
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The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties. |
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GO:0042176
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regulation of protein catabolic process
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Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. |
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GO:0044238
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primary metabolic process
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The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. |
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GO:0043085
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positive regulation of catalytic activity
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Any process that activates or increases the activity of an enzyme. |
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GO:0050790
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regulation of catalytic activity
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Any process that modulates the activity of an enzyme. |
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GO:0000278
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mitotic cell cycle
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Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
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GO:0051302
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regulation of cell division
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Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells. |
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GO:0044260
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cellular macromolecule metabolic process
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The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. |
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GO:0016043
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cellular component organization
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A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. |
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GO:0044267
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cellular protein metabolic process
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The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification. |
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GO:0009987
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cellular process
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Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. |
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GO:0097027
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ubiquitin-protein transferase activator activity
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Increases the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein. |
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GO:1904668
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positive regulation of ubiquitin protein ligase activity
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Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity. |
