GO Term : GO:0097619 PTEX complex GO

Namespace:  cellular_component Obsolete:  false
description  A protein complex that acts as a protein trafficking machinery and is responsible for the export of proteins across the parasitophorous (symbiont-containing) vacuolar membrane and into the human host cell. The PTEX complex is located in the vacuole membrane. It is ATP-powered, and comprises heat shock protein 101 (HSP101; a ClpA/B-like ATPase from the AAA+ superfamily, of a type commonly associated with protein translocons), a parasite protein termed PTEX150, and exported protein 2 (EXP2). EXP2 is the potential channel, as it is the membrane-associated component of the core PTEX complex. Two other proteins, PTEX88 and thioredoxin 2 (TRX2), were also identified as PTEX components.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

23 Parents

Identifier Name Description
GO:0043234 protein complex A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
GO:0005576 extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
GO:0030430 host cell cytoplasm The cytoplasm of a host cell.
GO:0032991 macromolecular complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
GO:0005575 cellular_component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
GO:0043227 membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GO:0043226 organelle Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
GO:0044422 organelle part Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
GO:0044421 extracellular region part Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
GO:0044215 other organism A secondary organism with which the first organism is interacting.
GO:0018995 host Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection.
GO:0033643 host cell part Any constituent part of a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO:0043657 host cell A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope.
GO:0043656 intracellular region of host That space within the plasma membrane of a host cell.
GO:0044217 other organism part Any constituent part of a secondary organism with which the first organism is interacting.
GO:0033646 host intracellular part Any constituent part of the living contents of a host cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO:0044216 other organism cell A cell of a secondary organism with which the first organism is interacting.
GO:0065010 extracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell.
GO:0020003 symbiont-containing vacuole Membrane-bounded vacuole within a host cell in which a symbiont organism resides. The vacuole membrane is derived from both the host and symbiont.
GO:0033655 host cell cytoplasm part Any constituent part of the host cell cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO:0043230 extracellular organelle Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi.
GO:0020005 symbiont-containing vacuole membrane The lipid bilayer surrounding a symbiont-containing vacuole, derived from both the host and symbiont.
GO:0097619 PTEX complex A protein complex that acts as a protein trafficking machinery and is responsible for the export of proteins across the parasitophorous (symbiont-containing) vacuolar membrane and into the human host cell. The PTEX complex is located in the vacuole membrane. It is ATP-powered, and comprises heat shock protein 101 (HSP101; a ClpA/B-like ATPase from the AAA+ superfamily, of a type commonly associated with protein translocons), a parasite protein termed PTEX150, and exported protein 2 (EXP2). EXP2 is the potential channel, as it is the membrane-associated component of the core PTEX complex. Two other proteins, PTEX88 and thioredoxin 2 (TRX2), were also identified as PTEX components.

27 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0044421 GO:0097619
is_a GO:0044422 GO:0097619
is_a GO:0033643 GO:0097619
part of GO:0020005 GO:0097619
is_a GO:0043234 GO:0097619
part of GO:0044217 GO:0097619
part of GO:0043227 GO:0097619
part of GO:0044216 GO:0097619
part of GO:0043226 GO:0097619
part of GO:0044215 GO:0097619
is_a GO:0005575 GO:0097619
part of GO:0020003 GO:0097619
part of GO:0005575 GO:0097619
part of GO:0005576 GO:0097619
is_a GO:0044217 GO:0097619
part of GO:0065010 GO:0097619
part of GO:0030430 GO:0097619
part of GO:0033643 GO:0097619
part of GO:0033646 GO:0097619
part of GO:0043656 GO:0097619
part of GO:0018995 GO:0097619
part of GO:0044422 GO:0097619
part of GO:0044421 GO:0097619
part of GO:0043657 GO:0097619
part of GO:0043230 GO:0097619
is_a GO:0032991 GO:0097619
part of GO:0033655 GO:0097619

1 Synonyms

Name Type
Plasmodium translocon of exported proteins synonym