GO Term : GO:1904233 negative regulation of aconitate hydratase activity GO
Namespace:  biological_process Obsolete:  false
description  Any process that stops, prevents or reduces the frequency, rate or extent of aconitate hydratase activity.
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0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

21 Parents

Identifier Name Description
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0008152 metabolic process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
GO:0016829 lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
GO:0050790 regulation of catalytic activity Any process that modulates the activity of an enzyme.
GO:0016836 hydro-lyase activity Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.
GO:0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme.
GO:0003994 aconitate hydratase activity Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.
GO:0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
GO:0003674 molecular_function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0019222 regulation of metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0065009 regulation of molecular function Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:0009892 negative regulation of metabolic process Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0048519 negative regulation of biological process Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0044092 negative regulation of molecular function Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:0016835 carbon-oxygen lyase activity Catalysis of the breakage of a carbon-oxygen bond.
GO:0051339 regulation of lyase activity Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
GO:0051350 negative regulation of lyase activity Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
GO:1904232 regulation of aconitate hydratase activity Any process that modulates the frequency, rate or extent of aconitate hydratase activity.
GO:1904233 negative regulation of aconitate hydratase activity Any process that stops, prevents or reduces the frequency, rate or extent of aconitate hydratase activity.

31 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
is_a GO:0065007 GO:1904233
negatively regulates GO:0003994 GO:1904233
negatively regulates GO:0003994 GO:1904233
is_a GO:0051350 GO:1904233
is_a GO:1904232 GO:1904233
is_a GO:0050790 GO:1904233
negatively regulates GO:0016829 GO:1904233
is_a GO:0008150 GO:1904233
regulates GO:0016836 GO:1904233
regulates GO:0008152 GO:1904233
regulates GO:0008150 GO:1904233
is_a GO:0044092 GO:1904233
regulates GO:0016835 GO:1904233
negatively regulates GO:0003824 GO:1904233
is_a GO:0065007 GO:1904233
is_a GO:0065009 GO:1904233
regulates GO:0003674 GO:1904233
regulates GO:0003994 GO:1904233
regulates GO:0016829 GO:1904233
is_a GO:0009892 GO:1904233
negatively regulates GO:0008152 GO:1904233
negatively regulates GO:0016835 GO:1904233
negatively regulates GO:0008150 GO:1904233
negatively regulates GO:0016836 GO:1904233
is_a GO:0051339 GO:1904233
is_a GO:0050789 GO:1904233
is_a GO:0019222 GO:1904233
is_a GO:0043086 GO:1904233
regulates GO:0003824 GO:1904233
negatively regulates GO:0003674 GO:1904233

24 Synonyms

Name Type
downregulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming) synonym
downregulation of cis-aconitase activity synonym
inhibition of aconitase activity synonym
downregulation of citrate(isocitrate) hydro-lyase activity synonym
inhibition of cis-aconitase activity synonym
inhibition of aconitate hydratase activity synonym
inhibition of citrate(isocitrate) hydro-lyase activity synonym
inhibition of citrate(isocitrate) hydro-lyase (cis-aconitate-forming) synonym
negative regulation of cis-aconitase activity synonym
negative regulation of aconitase activity synonym
negative regulation of citrate(isocitrate) hydro-lyase activity synonym
negative regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming) synonym
down regulation of aconitate hydratase activity synonym
down regulation of aconitase activity synonym
down regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming) synonym
down regulation of cis-aconitase activity synonym
down-regulation of aconitase activity synonym
down regulation of citrate(isocitrate) hydro-lyase activity synonym
down-regulation of cis-aconitase activity synonym
down-regulation of aconitate hydratase activity synonym
down-regulation of citrate(isocitrate) hydro-lyase activity synonym
down-regulation of citrate(isocitrate) hydro-lyase (cis-aconitate-forming) synonym
downregulation of aconitate hydratase activity synonym
downregulation of aconitase activity synonym