Protein Domain : IPR011576

Type:  Domain Name:  Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain
Description:  Pyridoxamine 5'-phosphate oxidase (PNPOx; ) is a FMN flavoprotein that catalyses the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP). This reaction serves as the terminal step in the de novo biosynthesis of PLP in Escherichia coli and as a part of the salvage pathway of this coenzyme in both E. coli and mammalian cells [, ]. The binding sites for FMN and for substrate have been highly conserved throughout evolution.This entry represents the FMN-binding domain present in pyridoxamine 5'-phosphate oxidases, as well as in a number of proteins that have not been demonstrated to have enzymatic activity. The FMN-binding domain has a structure consisting of a beta-barrel with Greek key topology, and is related to the ferredoxin reductase-like FAD-binding domain. PNPOx has a different dimerisation mode than that found in flavin reductases, which also carry an FMN-binding domain with a similar topology. Short Name:  Pyridox_Oxase_FMN-bd
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0 Child Features

0 Contains

1 Cross References

Identifier
PF01243

8 Found Ins

DB identifier Type Name
IPR012349 Domain FMN-binding split barrel
IPR000659 Family Pyridoxamine 5'-phosphate oxidase
IPR021198 Family Pyridoxamine 5'-phosphate oxidase, plant
IPR014419 Family Heme utilization protein with pyridoxamine 5'-phosphate domain
IPR019920 Domain F420-binding domain, putative
IPR019966 Family F420-dependent enzyme, PPOX class, family Rv3369, probable
IPR019967 Family F420-dependent enzyme, PPOX class, family Rv0121, probable
IPR019965 Family PPOX class F420-dependent enzyme, family Rv2061, putative

3 GO Annotations

GO Term Gene Name
GO:0004733 IPR011576
GO:0010181 IPR011576
GO:0055114 IPR011576

3 Ontology Annotations

GO Term Gene Name
GO:0004733 IPR011576
GO:0010181 IPR011576
GO:0055114 IPR011576

0 Parent Features

800 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
81184 D8R082 PAC:15406031 Selaginella moellendorffii 447  
evm.model.supercontig_51.125 PAC:16421790 Carica papaya 325  
evm.model.supercontig_96.56 PAC:16428998 Carica papaya 198  
43280.m000028 B9TLK8 PAC:16827587 Ricinus communis 147  
29115.m000024 B9TBK4 PAC:16802312 Ricinus communis 118  
orange1.1g025535m A0A067DZE7 PAC:18100405 Citrus sinensis 251  
orange1.1g021631m A0A067EIW5 PAC:18116118 Citrus sinensis 310  
orange1.1g018187m A0A067EUX2 PAC:18116109 Citrus sinensis 359  
orange1.1g020331m PAC:18116111 Citrus sinensis 327  
orange1.1g020336m A0A067EM92 PAC:18116110 Citrus sinensis 327  
orange1.1g020357m A0A067EM92 PAC:18116113 Citrus sinensis 327  
orange1.1g020335m PAC:18116112 Citrus sinensis 327  
orange1.1g020377m A0A067EM92 PAC:18116114 Citrus sinensis 327  
orange1.1g021284m A0A067EUX9 PAC:18116115 Citrus sinensis 314  
orange1.1g021293m A0A067EUX9 PAC:18116117 Citrus sinensis 314  
orange1.1g021298m A0A067EUX9 PAC:18116116 Citrus sinensis 314  
AT5G49970.1 Q9LTX3 PAC:19671695 Arabidopsis thaliana 530  
AT5G49970.2 Q9LTX3 PAC:19671696 Arabidopsis thaliana 466  
AT3G03890.1 Q8LDU1 PAC:19659747 Arabidopsis thaliana 321  
AT3G03890.2 Q93WM0 PAC:19659748 Arabidopsis thaliana 305  
AT2G46580.1 Q9ZPY1 PAC:19641051 Arabidopsis thaliana 198  
Thhalv10021141m V4M0S5 PAC:20181533 Eutrema salsugineum 323  
Thhalv10013217m V4LIW1 PAC:20204053 Eutrema salsugineum 533  
Ciclev10000790m V4V581 PAC:20785508 Citrus clementina 540  
Ciclev10001061m V4TBY4 PAC:20785510 Citrus clementina 467  
Ciclev10001064m V4TBY4 PAC:20785511 Citrus clementina 467  
Ciclev10000837m V4T6R1 PAC:20785509 Citrus clementina 526  
Ciclev10001362m V4T6T0 PAC:20788876 Citrus clementina 403  
Ciclev10001057m V4TBY8 PAC:20788875 Citrus clementina 467  
Ciclev10001359m V4T1Z9 PAC:20788877 Citrus clementina 403  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12824491
            12686112