| Type: | Family | Name: | Translation Initiation factor eIF- 4e-like |
| Description: | Eukaryotic translation initiation factor 4E (eIF-4E) [] is a protein thatbinds to the cap structure of eukaryotic cellular mRNAs. eIF-4E recognises and binds the 7-methylguanosine-containing (m7Gppp) cap during an early step in the initiationof protein synthesis and facilitates ribosome binding to a mRNA by inducing the unwinding of its secondary structures. A tryptophan in the central part of the sequence of humaneIF-4E seems to be implicated in cap-binding [].This entry includes a group of eIF4E-like protein. These proteins consist of a curved eight-stranded antiparallel beta-sheet, decorated with three helices on the convex face and three smaller helices inserted in connecting loops []. | Short Name: | TIF_eIF4e-like |
