Protein Domain : IPR006067

Type:  Domain Name:  Nitrite/sulphite reductase 4Fe-4S domain
Description:  Sulphite reductases (SiRs) and related nitrite reductases (NiRs) catalyse the six-electron reduction reactions of sulphite to sulphide, and nitrite to ammonia, respectively. The Escherichia coliSiR enzyme is a complex composed of two proteins, a flavoprotein alpha-component (SiR-FP) and a hemoprotein beta-component (SiR-HP) (), and has an alpha(8)beta(4) quaternary structure []. SiR-FP contains both FAD and FMN, while SiR-HP contains a Fe(4)S(4) cluster coupled to a siroheme through a cysteine bridge. Electrons are transferred from NADPH to FAD, and on to FMN in SiR-FP, from which they are transferred to the metal centre of SiR-HP, where they reduce the siroheme-bound sulphite.SiR-HP has a two-fold symmetry, which generates a distinctive three-domain alpha/beta fold that controls assembly and reactivity []. In the E. coli SiR-HP enzyme (), the iron is bound to cysteine residues at positions 433, 439, 478 and 482, the latter also forming the siroheme ligand. Short Name:  NO2/SO3_Rdtase_4Fe4S_dom
Paste the following link

0 Child Features

1 Contains

DB identifier Type Name
IPR006066 Binding_site Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site

1 Cross References

Identifier
PF01077

8 Found Ins

DB identifier Type Name
IPR011787 Family Sulphite reductase, ferredoxin dependent
IPR011786 Family Sulphite reductase (NADPH) hemoprotein, beta subunit
IPR012744 Domain Nitrite reductase [NAD(P)H] large subunit, NirB
IPR017121 Family Nitrite reductase [NAD(P)H], large subunit
IPR014261 Family Sulphite reductase, subunit C
IPR017220 Family Sulphite reductase, assimilatory
IPR011808 Family Sulphite reductase, dissimilatory-type beta subunit
IPR011806 Family Sulphite reductase, dissimilatory-type alpha subunit

4 GO Annotations

GO Term Gene Name
GO:0016491 IPR006067
GO:0020037 IPR006067
GO:0051536 IPR006067
GO:0055114 IPR006067

4 Ontology Annotations

GO Term Gene Name
GO:0016491 IPR006067
GO:0020037 IPR006067
GO:0051536 IPR006067
GO:0055114 IPR006067

0 Parent Features

919 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
178021 D8S9G0 PAC:15403859 Selaginella moellendorffii 604  
230718 D8R4B6 PAC:15416111 Selaginella moellendorffii 596  
evm.model.supercontig_62.8 PAC:16424045 Carica papaya 586  
evm.model.supercontig_942.3 PAC:16428828 Carica papaya 364  
29801.m003182 B9RYH9 PAC:16809032 Ricinus communis 587  
30169.m006441 B9RIC6 PAC:16821241 Ricinus communis 689  
Cucsa.143430.1 PAC:16963789 Cucumis sativus 751  
Cucsa.244280.1 A0A0A0L6H3 PAC:16971284 Cucumis sativus 583  
orange1.1g005564m A0A067FDH3 PAC:18124099 Citrus sinensis 691  
orange1.1g005543m A0A067FCS6 PAC:18124100 Citrus sinensis 691  
orange1.1g008202m A0A067F1P0 PAC:18124101 Citrus sinensis 574  
orange1.1g047572m A0A067EXB3 PAC:18100161 Citrus sinensis 595  
AT5G04590.1 Q9LZ66 PAC:19665499 Arabidopsis thaliana 642  
AT2G15620.1 Q39161 PAC:19639682 Arabidopsis thaliana 586  
Thhalv10022613m V4M7L4 PAC:20202375 Eutrema salsugineum 590  
Thhalv10020266m V4NQW9 PAC:20181884 Eutrema salsugineum 645  
Thhalv10020267m V4NQW9 PAC:20181885 Eutrema salsugineum 645  
Thhalv10020269m V4NQW9 PAC:20181883 Eutrema salsugineum 645  
Thhalv10020247m V4M2G9 PAC:20181882 Eutrema salsugineum 655  
Ciclev10028067m V4UAH2 PAC:20812935 Citrus clementina 595  
Ciclev10014382m V4U5K8 PAC:20816702 Citrus clementina 754  
Ciclev10014381m V4UAV9 PAC:20816701 Citrus clementina 754  
Lus10014059 PAC:23156821 Linum usitatissimum 588  
Lus10030131 PAC:23172600 Linum usitatissimum 687  
Lus10009951 PAC:23150117 Linum usitatissimum 687  
Lus10014907 PAC:23152783 Linum usitatissimum 771  
Lus10027360 PAC:23145447 Linum usitatissimum 702  
Potri.009G052600.1 A0A2K1Z345 PAC:26985947 Populus trichocarpa 690  
Potri.009G052600.3 PAC:26985949 Populus trichocarpa 535  
Potri.009G052600.2 A0A2K1Z345 PAC:26985948 Populus trichocarpa 690  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10984484
            7569952