| Type: | Family | Name: | Adaptor protein complex AP-2, alpha subunit |
| Description: | The adaptor protein complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. The adaptor protein complex 2 (AP-2) appears to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface.AP-2 is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). It is a component of a complex composed at least of ACTB, AP2M1, AP2A1, AP2A2, MEGF10 and VIM, which interacts with RAB11FIP2. The subunits of clathrin-associated adaptor protein complex 2 play a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or in endosomes. This group represents an adaptor protein complex AP-2, alpha subunit. | Short Name: | AP2_complex_asu |
| DB identifier | Type | Name |
|---|---|---|
| IPR003164 | Domain | Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain |
| IPR008152 | Domain | Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain |
| IPR011989 | Domain | Armadillo-like helical |
| IPR002553 | Domain | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
| IPR013038 | Domain | Clathrin adaptor, alpha-adaptin, appendage, Ig-like subdomain |
| GO Term | Gene Name |
|---|---|
| GO:0008565 | IPR017104 |
| GO:0015031 | IPR017104 |
| GO:0016020 | IPR017104 |
