Protein Domain : IPR001309

Type:  Domain Name:  Peptidase C14, ICE, catalytic subunit p20
Description:  This group of sequences represent the p20 subunit found in caspases. Caspases are composed of an N-terminal pro-domain that is cleaved during activation, and C-terminal catalytic and interaction domains []. All caspases contain two essential caspase catalytic domains: the p20 subunit (20 kDa) and the p10 subunit (10 kDa) (), which are derived from the p45 (45 kDa) precursor (). Caspases are tightly regulated proteins that require zymogen activation to become active, and once active can be regulated by caspase inhibitors. Activated caspases are cysteine proteases (MEROPS clan CD, family C14) that use the sulphydryl group of a cysteine side chain for catalysing peptide bond cleavage at aspartyl residues in their substrates. The key catalytic residues, a cysteine and a histidine, are on the p20 subunit.Caspases are mainly involved in mediating cell death (apoptosis), either as initiators that trigger the cell death process, or as effectors of the process itself [, ]. At the end of the cascade, caspases act on a variety of signal transduction proteins, cytoskeletal and nuclear proteins, chromatin-modifying proteins, DNA repair proteins and endonucleases that destroy the cell by disintegrating its contents, including its DNA. Caspases can have roles other than in apoptosis, such as caspase-1 (interleukin-1 beta convertase) (), which is involved in the inflammatory process. The activation of apoptosis can sometimes lead to caspase-1 activation, providing a link between apoptosis and inflammation, such as during the targeting of infected cells. Caspases may also be involved in cell differentiation []. Short Name:  Pept_C14_ICE_p20
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0 Child Features

1 Contains

DB identifier Type Name
IPR016129 Active_site Peptidase C14, ICE, catalytic subunit p20, active site

1 Cross References

Identifier
PS50208

4 Found Ins

DB identifier Type Name
IPR011600 Domain Peptidase C14, caspase domain
IPR015917 Domain Peptidase C14A, caspase precursor p45, core
IPR015470 Family Caspase-3
IPR017350 Family Caspase, interleukin-1 beta convertase-type

2 GO Annotations

GO Term Gene Name
GO:0004197 IPR001309
GO:0006508 IPR001309

2 Ontology Annotations

GO Term Gene Name
GO:0004197 IPR001309
GO:0006508 IPR001309

1 Parent Features

DB identifier Type Name
IPR029030 Domain Caspase-like domain

9 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Mapoly0052s0114.1.p A0A2R6WWW4 PAC:33026716 Marchantia polymorpha 807  
Mapoly0108s0037.1.p A0A2R6WCW2 PAC:33021780 Marchantia polymorpha 807  
Dusal.0056s00016.1.p PAC:33188763 Dunaliella salina 645  
Dusal.0056s00016.2.p PAC:33188764 Dunaliella salina 643  
CepurR40.5G008800.1.p PAC:43020773 Ceratodon purpureus R40 1147  
CepurR40.5G008700.1.p PAC:43019727 Ceratodon purpureus R40 1508  
CepurGG1.5G009900.1.p PAC:43038693 Ceratodon purpureus GG1 1856  
CepurGG1.5G009700.1.p PAC:43040203 Ceratodon purpureus GG1 1149  
CepurGG1.5G009500.1.p PAC:43040443 Ceratodon purpureus GG1 1385  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15226512
            15077141
            15066636
            10578171