Protein Domain : IPR015470

Type:  Family Name:  Caspase-3
Description:  The molecular hallmark of programmed cell death, or apoptosis, is the activation of caspases. Caspases are synthesized as relatively inactive zymogens and must undergo a process of activation during apoptosis. Based on their order of activation, caspases are classified into two families: the initiator caspases, caspase-2, -8, -9, -10,and -11, and the effector caspases, caspase-3, -6, and -7. In response to upstream apoptotic stimuli, the initiator caspases undergo a complex course of autocatalytic processing and activation, which usually require several auxiliary factors []. Once activated, an initiator caspase specifically cleaves and hence activates an effector caspase zymogen.The family of caspases include []: caspase-1 (interleukin-beta1 converting enzyme); caspase-2 (ICH-1, NEDD-2); caspase-3 (apopain, CPP32, Yama); caspase-4 (ICH-2, TX, ICErel-II); caspase-5 (ICH-3, TY, ICErel-III); caspase-6 (MCH-2); caspase-7 (MCH-3, ICE-LAP3, CMH-1, SCA-2, LICE2); caspase-8 (MCH-5, MACH, FLICE); caspase-9 (MCH-6, ICE-LAP6); caspase-10 (MCH-4, FLICE2); caspase-11; caspase-12; caspase-13; caspase 14 (MICE); Caenorhabditis elegansced-3; Danio rerio(Zebrafish) (Brachydanio rerio) caspy; and Drosophila melanogasterIce.Caspase-3-deficient born at a frequency lower than expected by Mendelian genetics, are smaller than their littermates and die at 1-3 weeks of age. Although their thymocytes retain normal susceptibility to various apoptotic stimuli, brain development in caspase-3-deficient mice is profoundly affected, and discernible by embryonic day 12, resulting in a variety of hyperplasias and disorganised cell deployment []. Caspase-9 cleaves and activates caspase-3, and caspase-9 deficient Mus musculus(Mouse) show no caspase3 activation in embryonic brains in vivo []. Short Name:  Caspase_3
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0 Child Features

4 Contains

DB identifier Type Name
IPR015917 Domain Peptidase C14A, caspase precursor p45, core
IPR001309 Domain Peptidase C14, ICE, catalytic subunit p20
IPR002138 Domain Peptidase C14, caspase non-catalytic subunit p10
IPR016129 Active_site Peptidase C14, ICE, catalytic subunit p20, active site

1 Cross References

Identifier
PTHR10454:SF30

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004197 IPR015470
GO:0006508 IPR015470
GO:0006915 IPR015470
GO:0005737 IPR015470

4 Ontology Annotations

GO Term Gene Name
GO:0004197 IPR015470
GO:0006508 IPR015470
GO:0006915 IPR015470
GO:0005737 IPR015470

0 Parent Features

0 Proteins

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8861900
            11931755
            8934524
            9708735