Protein Domain : IPR002109

Type:  Domain Name:  Glutaredoxin
Description:  Glutaredoxins [, , ], also known as thioltransferases (disulphide reductases, are small proteins of approximately one hundred amino-acid residues which utilise glutathione and NADPH as cofactors. Oxidized glutathione is regenerated by glutathione reductase. Together these components compose the glutathione system []. Glutaredoxin functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. Like thioredoxin, which functions in a similar way, glutaredoxin possesses an active centre disulphide bond []. It exists in either a reduced or an oxidized form where the two cysteine residues are linked in an intramolecular disulphide bond.Glutaredoxin has been sequenced in a variety of species. On the basis of extensive sequence similarity, it has been proposed [] that Vaccinia virusprotein O2L is most probably a glutaredoxin. Finally, it must be noted that Bacteriophage T4thioredoxin seems also to be evolutionary related. In position 5 of the pattern T4 thioredoxin has Val instead of Pro.This entry represents Glutaredoxin. Short Name:  Glutaredoxin

1 Child Features

DB identifier Type Name
IPR014025 Domain Glutaredoxin subgroup

1 Contains

DB identifier Type Name
IPR011767 Active_site Glutaredoxin active site

2 Cross Referencess


11 Found Ins

DB identifier Type Name
IPR012336 Domain Thioredoxin-like fold
IPR014434 Family Monothiol glutaredoxin
IPR004480 Family Monothiol glutaredoxin-related
IPR011905 Family Glutaredoxin-like, plant II
IPR011900 Family Glutaredoxin, GrxC
IPR011909 Family Glutaredoxin-like protein NrdH
IPR004502 Family Thioredoxins/glutaredoxin
IPR011902 Family Glutaredoxin, GrxA
IPR011903 Family Glutaredoxin-like domain
IPR011911 Family Glutaredoxin-like protein, YruB
IPR011915 Family Glutaredoxin-like protein, actinobacteria

3 GO Annotations

GO Term Gene Name
GO:0009055 IPR002109
GO:0015035 IPR002109
GO:0045454 IPR002109

3 Ontology Annotations

GO Term Gene Name
GO:0009055 IPR002109
GO:0015035 IPR002109
GO:0045454 IPR002109

0 Parent Features

3279 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
15619 D8RGY4 PAC:15415751 Selaginella moellendorffii 164  
19369 D8RQG2 PAC:15402832 Selaginella moellendorffii 89  
102863 D8RVH1 PAC:15409242 Selaginella moellendorffii 110  
174566 D8RV58 PAC:15418531 Selaginella moellendorffii 131  
103322 D8RW70 PAC:15408146 Selaginella moellendorffii 272  
150447 D8RW56 PAC:15414071 Selaginella moellendorffii 483  
80143 D8QWY7 PAC:15402987 Selaginella moellendorffii 103  
107780 D8S318 PAC:15423013 Selaginella moellendorffii 184  
80915 D8R0F3 PAC:15409110 Selaginella moellendorffii 198  
57444 D8SCJ2 PAC:15404129 Selaginella moellendorffii 249  
116000 D8SFW5 PAC:15421777 Selaginella moellendorffii 163  
445456 D8SIT0 PAC:15419601 Selaginella moellendorffii 124  
407623 D8R674 PAC:15420457 Selaginella moellendorffii 280  
85254 D8R4X3 PAC:15418476 Selaginella moellendorffii 99  
123396 D8SRX5 PAC:15422740 Selaginella moellendorffii 330  
229902 D8QQY2 PAC:15414439 Selaginella moellendorffii 103  
89111 D8RBN6 PAC:15406906 Selaginella moellendorffii 103  
88036 D8R9D3 PAC:15403283 Selaginella moellendorffii 122  
68277 D8R959 PAC:15412915 Selaginella moellendorffii 166  
127444 D8SY53 PAC:15412833 Selaginella moellendorffii 117  
evm.TU.contig_31216.1 PAC:16429954 Carica papaya 102  
evm.TU.contig_34363.1 PAC:16430436 Carica papaya 102  
evm.TU.contig_44554.1 PAC:16432036 Carica papaya 258  
evm.model.supercontig_10.223 PAC:16404586 Carica papaya 119  
evm.model.supercontig_108.33 PAC:16405448 Carica papaya 107  
evm.model.supercontig_1080.2 PAC:16405504 Carica papaya 135  
evm.model.supercontig_11.97 PAC:16405768 Carica papaya 327  
evm.model.supercontig_115.53 PAC:16406219 Carica papaya 140  
evm.model.supercontig_14.17 PAC:16408669 Carica papaya 294  
evm.model.supercontig_1467.1 PAC:16409177 Carica papaya 283  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID