Protein Domain : IPR000073

Type:  Domain Name:  Alpha/beta hydrolase fold-1
Description:  The alpha/beta hydrolase fold [] is common to a number of hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The core of each enzyme is an alpha/beta-sheet (rather than a barrel), containing 8 strands connected by helices []. The enzymes are believed to have diverged from a common ancestor, preserving the arrangement of the catalytic residues. All have a catalytic triad, the elements of which are borne on loops, which are the best conserved structural features of the fold. Esterase (EST) from Pseudomonas putidais a member of the alpha/beta hydrolase fold superfamily of enzymes [].In most of the family members the beta-strands are parallels, but some have an inversion of the first strands, which gives it an antiparallel orientation. The catalytic triad residues are presented on loops. One of these is the nucleophile elbow and is the most conserved feature of the fold. Some other members lack one or all of the catalytic residues. Some members are therefore inactive but others are involved in surface recognition. The ESTHER database [] gathers and annotates all the published information related to gene and protein sequences of this superfamily [].This entry represents fold-1 of alpha/beta hydrolase. Short Name:  AB_hydrolase_1
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0 Child Features

1 Contains

DB identifier Type Name
IPR000952 Conserved_site Uncharacterised protein family UPF0017, hydrolase-like, conserved site

3 Cross Referencess

Identifier
PF00561
PF12697
PR00111

12 Found Ins

DB identifier Type Name
IPR012020 Family AB-hydrolase ABHD1/2/3
IPR016812 Family Protein phosphatase methylesterase, eukaryotic
IPR008220 Family Homoserine acetyltransferase
IPR016292 Family Epoxide hydrolase
IPR022485 Family 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
IPR017209 Family Alpha/beta hydrolase, predicted
IPR005945 Family Proline-specific peptidase
IPR010076 Family Pimeloyl-[acyl-carrier protein] methyl ester esterase
IPR010125 Family Poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit
IPR010963 Family Poly(R)-hydroxyalkanoic acid synthase, class I
IPR011287 Family Poly(R)-hydroxyalkanoic acid synthase, class II
IPR017727 Family 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase, BphD

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR029058 Domain Alpha/Beta hydrolase fold

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
92150 D8RF38 PAC:15416166 Selaginella moellendorffii 391  
92683 D8RGA7 PAC:15420028 Selaginella moellendorffii 318  
92534 D8RFX8 PAC:15419167 Selaginella moellendorffii 297  
24191 D8TAU5 PAC:15416337 Selaginella moellendorffii 280  
172238 D8RKL6 PAC:15410370 Selaginella moellendorffii 368  
96082 D8RKM6 PAC:15404698 Selaginella moellendorffii 276  
97686 D8RMD3 PAC:15412356 Selaginella moellendorffii 457  
97826 D8RMU1 PAC:15413804 Selaginella moellendorffii 337  
165504 D8QUY6 PAC:15414210 Selaginella moellendorffii 301  
438125 D8QU92 PAC:15418822 Selaginella moellendorffii 301  
77914 D8QWA0 PAC:15422286 Selaginella moellendorffii 379  
413295 D8RP00 PAC:15413107 Selaginella moellendorffii 590  
441991 D8RPH7 PAC:15411863 Selaginella moellendorffii 267  
98191 D8RP44 PAC:15411494 Selaginella moellendorffii 299  
97995 D8RPK6 PAC:15414745 Selaginella moellendorffii 294  
98381 D8RPJ5 PAC:15412989 Selaginella moellendorffii 293  
173531 D8RRE8 PAC:15415592 Selaginella moellendorffii 302  
414127 D8RRQ9 PAC:15415089 Selaginella moellendorffii 516  
100032 D8RRT9 PAC:15419510 Selaginella moellendorffii 317  
100200 D8RS65 PAC:15420940 Selaginella moellendorffii 301  
100780 D8RRV2 PAC:15402596 Selaginella moellendorffii 312  
100775 D8RRT8 PAC:15402576 Selaginella moellendorffii 312  
414679 D8RTK2 PAC:15419032 Selaginella moellendorffii 252  
101768 D8RU55 PAC:15405498 Selaginella moellendorffii 322  
102385 D8RVM7 PAC:15405389 Selaginella moellendorffii 285  
438482 D8QYE5 PAC:15421152 Selaginella moellendorffii 465  
79445 D8QYI5 PAC:15402148 Selaginella moellendorffii 321  
80187 D8QYD9 PAC:15403080 Selaginella moellendorffii 311  
80078 D8QWJ9 PAC:15402333 Selaginella moellendorffii 142  
106067 D8S0V0 PAC:15414910 Selaginella moellendorffii 577  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1409539
            16321951
            14681380