Protein Domain : IPR006121

Type:  Domain Name:  Heavy metal-associated domain, HMA
Description:  Proteins that transport heavy metals in micro-organisms and mammals share similarities in their sequences and structures.These proteins provide an important focus for research, some being involved in bacterial resistance to toxic metals, such as lead and cadmium, while others are involved in inherited human syndromes, such as Wilson's and Menke's diseases []. A conserved domain has been found in a number of these heavy metal transport or detoxification proteins []. The domain, which has been termed Heavy-Metal-Associated (HMA), contains two conserved cysteines that are probably involved in metal binding.Structure solution of the fourth HMA domain of the Menke's copper transporting ATPase shows a well-defined structure comprising a four-stranded antiparallelbeta-sheet and two alpha helices packed in an alpha-beta sandwich fold []. This fold is common to other domains and is classifiedas "ferredoxin-like". Short Name:  HMA_dom
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1 Child Features

DB identifier Type Name
IPR006122 Domain Heavy metal-associated domain, copper ion-binding

1 Contains

DB identifier Type Name
IPR017969 Conserved_site Heavy-metal-associated, conserved site

3 Cross Referencess

Identifier
PF00403
PS50846
SSF55008

5 Found Ins

DB identifier Type Name
IPR001757 Family P-type ATPase
IPR016578 Family Chloroplast-targeted copper chaperone, predicted
IPR021179 Family Mercury(II) reductase
IPR016617 Family Uncharacterised conserved protein UCP013899, metal binding
IPR000579 Family Cation-transporting P-type ATPase A/B

2 GO Annotations

GO Term Gene Name
GO:0046872 IPR006121
GO:0030001 IPR006121

2 Ontology Annotations

GO Term Gene Name
GO:0046872 IPR006121
GO:0030001 IPR006121

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
231359 D8REZ4 PAC:15416074 Selaginella moellendorffii 924  
92276 D8RFP0 PAC:15416970 Selaginella moellendorffii 953  
9116 D8RFT6 PAC:15405700 Selaginella moellendorffii 80  
431418 D8TCK0 PAC:15422829 Selaginella moellendorffii 684  
441944 D8RP11 PAC:15411748 Selaginella moellendorffii 167  
441945 D8RP12 PAC:15411749 Selaginella moellendorffii 321  
149298 D8RRX0 PAC:15409342 Selaginella moellendorffii 781  
414420 D8RSP5 PAC:15417329 Selaginella moellendorffii 235  
174037 D8RT71 PAC:15414733 Selaginella moellendorffii 113  
442588 D8RU79 PAC:15411709 Selaginella moellendorffii 606  
9124 D8RWT0 PAC:15405727 Selaginella moellendorffii 61  
442871 D8RWS9 PAC:15414037 Selaginella moellendorffii 277  
438508 D8QWF0 PAC:15421721 Selaginella moellendorffii 604  
60775 D8QYH6 PAC:15415709 Selaginella moellendorffii 790  
109953 D8S6P6 PAC:15408007 Selaginella moellendorffii 70  
153588 D8S967 PAC:15423482 Selaginella moellendorffii 217  
233397 D8S8J9 PAC:15421876 Selaginella moellendorffii 817  
111936 D8S9X3 PAC:15414288 Selaginella moellendorffii 125  
118425 D8SJM4 PAC:15408435 Selaginella moellendorffii 831  
84115 D8R2W8 PAC:15414789 Selaginella moellendorffii 960  
122320 D8SPX5 PAC:15419732 Selaginella moellendorffii 1018  
446343 D8SQL6 PAC:15421615 Selaginella moellendorffii 155  
29653 D8R531 PAC:15412400 Selaginella moellendorffii 63  
439537 D8R5S7 PAC:15402438 Selaginella moellendorffii 123  
439536 D8R5S6 PAC:15402436 Selaginella moellendorffii 155  
39115 D8QQI3 PAC:15415707 Selaginella moellendorffii 73  
129166 D8T0I2 PAC:15416398 Selaginella moellendorffii 904  
169899 D8RBE6 PAC:15405944 Selaginella moellendorffii 88  
89397 D8RBL1 PAC:15408658 Selaginella moellendorffii 819  
60690 D8QRZ3 PAC:15414992 Selaginella moellendorffii 696  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8091505
            9437429