Protein Domain : IPR006122

Type:  Domain Name:  Heavy metal-associated domain, copper ion-binding
Description:  Proteins that transport heavy metals in micro-organisms and eukaryotes share similarities in their sequences and structures.These proteins provide an important focus for research, some being involved in bacterial resistance to toxic metals, such as lead and cadmium, while others are involved in inherited human syndromes, such as Wilson's and Menke's diseases []. A conserved 30-residue domain has been found in a number of these heavy metal transport or detoxification proteins []. The domain, which has been termed Heavy-Metal-Associated (HMA), contains two conserved cysteines that are probably involved in metal binding. This sub-domain is found in copper-binding proteins. Short Name:  HMA_Cu_ion-bd
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0 Child Features

1 Contains

DB identifier Type Name
IPR017969 Conserved_site Heavy-metal-associated, conserved site

1 Cross References

Identifier
TIGR00003

1 Found In

DB identifier Type Name
IPR000428 Family Copper ion binding protein

1 GO Annotation

GO Term Gene Name
GO:0005507 IPR006122

1 Ontology Annotations

GO Term Gene Name
GO:0005507 IPR006122

1 Parent Features

DB identifier Type Name
IPR006121 Domain Heavy metal-associated domain, HMA

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
231359 D8REZ4 PAC:15416074 Selaginella moellendorffii 924  
92276 D8RFP0 PAC:15416970 Selaginella moellendorffii 953  
233397 D8S8J9 PAC:15421876 Selaginella moellendorffii 817  
84115 D8R2W8 PAC:15414789 Selaginella moellendorffii 960  
122320 D8SPX5 PAC:15419732 Selaginella moellendorffii 1018  
evm.model.supercontig_162.49 PAC:16410273 Carica papaya 984  
evm.model.supercontig_30.132 PAC:16416925 Carica papaya 901  
evm.model.supercontig_74.17 PAC:16425705 Carica papaya 942  
evm.model.supercontig_84.72 PAC:16427357 Carica papaya 1025  
29840.m000632 PAC:16810452 Ricinus communis 1001  
30169.m006419 B9RIA4 PAC:16821219 Ricinus communis 968  
30190.m011197 B9RC99 PAC:16823554 Ricinus communis 987  
Cucsa.048720.1 A0A0A0KPC0 PAC:16953908 Cucumis sativus 1007  
Cucsa.048720.2 PAC:16953909 Cucumis sativus 734  
orange1.1g039776m PAC:18118382 Citrus sinensis 922  
orange1.1g002427m A0A067GPE6 PAC:18139158 Citrus sinensis 924  
orange1.1g004259m A0A067GPP7 PAC:18139160 Citrus sinensis 765  
orange1.1g008590m A0A067GPF0 PAC:18139161 Citrus sinensis 560  
orange1.1g001896m A0A067GCH6 PAC:18139156 Citrus sinensis 998  
orange1.1g001906m A0A067GC79 PAC:18139157 Citrus sinensis 997  
orange1.1g003131m A0A067GF65 PAC:18139159 Citrus sinensis 845  
orange1.1g001984m A0A067FCX4 PAC:18124095 Citrus sinensis 986  
orange1.1g001985m A0A067FCX4 PAC:18124096 Citrus sinensis 986  
orange1.1g001981m A0A067FCX4 PAC:18124097 Citrus sinensis 986  
AT5G44790.1 Q9S7J8 PAC:19665355 Arabidopsis thaliana 1001  
AT1G63440.1 Q9SH30 PAC:19650287 Arabidopsis thaliana 995  
Thhalv10000758m V4LB28 PAC:20202842 Eutrema salsugineum 1012  
Ciclev10018819m V4TMD3 PAC:20808634 Citrus clementina 868  
Ciclev10023463m V4TSD6 PAC:20809324 Citrus clementina 855  
Ciclev10014141m V4UCI6 PAC:20818235 Citrus clementina 998  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8091505