Type: | Domain | Name: | Ku70/Ku80, N-terminal alpha/beta |
Description: | The Ku heterodimer (composed of Ku70 and Ku80 ) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the N-terminal alpha/beta domain. This domain only makes a small contribution to the dimer interface. The domain comprises a six stranded beta sheet of the Rossman fold []. | Short Name: | Ku_N |