Protein Domain : IPR006165

Type:  Family Name:  Ku70
Description:  Members are primarily Ku70 domain-containing proteins. Ku70 is a eukaryotic protein that is involved in the repair of DNA double-strand breaks by non-homologous end-joining [, ]. Ku is a heterodimer of approximately 70 kDa and 80 kDa subunits []. Both these subunits have strong sequence similarity and it has been suggested that they may have evolved by gene duplication from a homodimeric ancestor in eukaryotes []. Homologues of the eukaryotic DNA-end-binding protein Ku were identified in several bacterial and one archaeal genome using iterative database searches; these prokaryotic Ku members are homodimers that have been predicted to be involved in the DNA repair system, which is mechanistically similar to eukaryotic non-homologous end joining [, ] though they are not members of this family. Recent findings have implicated yeast Ku in telomeric structure maintenance in addition to non-homologous end-joining. Some of the phenotypes of Ku-knockout mice may indicate a similar role for Ku at mammalian telomeres [].Evolutionary notes: With the current available phyletic information it is difficult to determine the correct evolutionary trajectory of the Ku domain. It is possible that the core Ku domain was present in bacteria and archaea even before the presence of the eukaryotes. Eukaryotes might have vertically inherited the Ku core protein from a common ancestor shared with a certain archaeal lineage, or through horizontal transfer from bacteria. Alternatively, the core Ku domain could have evolved in the eukaryotic lineage and then horizontally transferred to the prokaryotes. Sequencing of additional archaeal genomes and those of early-branching eukaryotes may help resolve the evolutionary history of the Ku domain. Structure notes: The eukaryotic Ku heterodimer is comprised of an alpha/beta N-terminal, a central beta-barrel domain and a helical C-terminal arm []. Structural analysis of the Ku70/80 heterodimer bound to DNA indicates that subunit contacts lead to the formation of a highly charged channel through which the DNA passes without making any contacts with the DNA bases [].For additional information please see []. Short Name:  Ku70

0 Child Features

4 Contains

DB identifier Type Name
IPR005161 Domain Ku70/Ku80, N-terminal alpha/beta
IPR005160 Domain Ku70/Ku80 C-terminal arm
IPR006164 Domain Ku70/Ku80 beta-barrel domain
IPR016194 Domain SPOC-like, C-terminal domain

3 Cross Referencess

Identifier
PTHR12604:SF2
PIRSF003033
TIGR00578

0 Found In

7 GO Annotations

GO Term Gene Name
GO:0003677 IPR006165
GO:0003684 IPR006165
GO:0042162 IPR006165
GO:0000723 IPR006165
GO:0006303 IPR006165
GO:0005634 IPR006165
GO:0043564 IPR006165

7 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR006165
GO:0003684 IPR006165
GO:0042162 IPR006165
GO:0000723 IPR006165
GO:0006303 IPR006165
GO:0005634 IPR006165
GO:0043564 IPR006165

0 Parent Features

516 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
165509 D8QUY9 PAC:15414214 Selaginella moellendorffii 564  
78255 D8QU89 PAC:15420050 Selaginella moellendorffii 565  
evm.model.supercontig_77.50 PAC:16426108 Carica papaya 440  
29634.m002087 B9S6B3 PAC:16804228 Ricinus communis 626  
Cucsa.094430.3 PAC:16957742 Cucumis sativus 610  
Cucsa.094430.1 PAC:16957740 Cucumis sativus 625  
Cucsa.094430.2 PAC:16957741 Cucumis sativus 614  
orange1.1g006975m PAC:18133788 Citrus sinensis 623  
AT1G16970.1 Q9FQ08 PAC:19651666 Arabidopsis thaliana 621  
Thhalv10007085m V4KYL6 PAC:20186683 Eutrema salsugineum 620  
Ciclev10019318m V4VRF5 PAC:20811126 Citrus clementina 623  
Lus10005783 PAC:23174719 Linum usitatissimum 554  
Lus10006818 PAC:23150749 Linum usitatissimum 598  
Potri.011G107000.2 A0A2K1YIE6 PAC:27002310 Populus trichocarpa 132  
Potri.011G107400.2 A0A2K1YIE7 PAC:27001138 Populus trichocarpa 627  
Potri.011G107400.1 PAC:27001137 Populus trichocarpa 628  
Potri.011G107000.1 PAC:27002309 Populus trichocarpa 134  
Gorai.002G052100.1 A0A0D2Q120 PAC:26792124 Gossypium raimondii 624  
42298 I0YW72 PAC:27388483 Coccomyxa subellipsoidea C-169 612  
60892 C1FGI7 PAC:27403318 Micromonas sp RCC299 780  
24969 A4S1U1 PAC:27419499 Ostreococcus lucimarinus 341  
Thecc1EG031961t3 A0A061F9K2 PAC:27445582 Theobroma cacao 529  
Thecc1EG031961t2 A0A061F8L8 PAC:27445583 Theobroma cacao 508  
Thecc1EG031961t1 A0A061F7R3 PAC:27445581 Theobroma cacao 628  
Migut.N00440.1.p A0A022QXU9 PAC:28925880 Mimulus guttatus 623  
Araha.2449s0007.1.p PAC:28852816 Arabidopsis halleri 621  
Cagra.0824s0066.1.p PAC:28899938 Capsella grandiflora 620  
Glyma.10G297800.1.p A0A0R0I7S2 PAC:30478198 Glycine max 181  
Glyma.20G248800.2.p I1NJE1 PAC:30520506 Glycine max 627  
Glyma.20G248800.1.p K7N5J8 PAC:30520505 Glycine max 634  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11493912
            11483577
            11839498
            10377944
            11445083
            11516951
            9477961