Protein Domain : IPR016194

Type:  Domain Name:  SPOC-like, C-terminal domain
Description:  This entry represents the Spen Paralogue and Orthologue C-terminal (SPOC) domain and its structural homologues. This domain has a closed beta-barrel fold of complex topology. Proteins that carry a SPOC-like domain include:Spen proteins, such as SHARP (SMRT/HDAC1-associated repressor protein), which carry a SPOC domain at the C-terminal and an RNA-binding motif in the N-terminal; Spen proteins regulate the expression of key transcriptional effectors in diverse signalling pathways, the SHARP protein being a component of transcriptional repression complexes in both nuclear receptor and Notch/RBP-Jkappa signalling pathways [].The middle domains of Ku70 and Ku80 (which includes the C-terminal alpha-helical arm and the DNA encircling insertion); the Ku heterodimer, which is composed of Ku70 and Ku80 subunits, contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway []. Short Name:  SPOC-like_C_dom

0 Child Features

3 Contains

DB identifier Type Name
IPR005160 Domain Ku70/Ku80 C-terminal arm
IPR006164 Domain Ku70/Ku80 beta-barrel domain
IPR010912 Domain Spen paralogue/orthologue C-terminal, metazoa

2 Cross Referencess

Identifier
G3DSA:2.40.290.10
SSF100939

2 Found Ins

DB identifier Type Name
IPR006165 Family Ku70
IPR009187 Family Non-homologous end joining protein Ku, prokaryotic type

0 GO Annotation

0 Ontology Annotations

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
165509 D8QUY9 PAC:15414214 Selaginella moellendorffii 564  
404086 D8QU86 PAC:15407110 Selaginella moellendorffii 694  
404323 D8QUZ3 PAC:15409378 Selaginella moellendorffii 702  
78255 D8QU89 PAC:15420050 Selaginella moellendorffii 565  
74928 D8QMI2 PAC:15413716 Selaginella moellendorffii 701  
evm.model.supercontig_136.82 PAC:16408377 Carica papaya 837  
evm.model.supercontig_18.115 PAC:16411255 Carica papaya 698  
evm.model.supercontig_77.50 PAC:16426108 Carica papaya 440  
evm.model.supercontig_9.316 PAC:16428220 Carica papaya 832  
29904.m002975 B9RWK8 PAC:16812620 Ricinus communis 103  
30005.m001243 B9SEZ1 PAC:16815476 Ricinus communis 929  
30170.m013748 B9R712 PAC:16821594 Ricinus communis 2020  
30174.m008890 B9RDD3 PAC:16822534 Ricinus communis 684  
29634.m002087 B9S6B3 PAC:16804228 Ricinus communis 626  
29640.m000404 B9SYX4 PAC:16804458 Ricinus communis 391  
29577.m000447 B9SU08 PAC:16803045 Ricinus communis 902  
Cucsa.362180.1 PAC:16980897 Cucumis sativus 775  
Cucsa.352770.1 PAC:16980048 Cucumis sativus 285  
Cucsa.094430.3 PAC:16957742 Cucumis sativus 610  
Cucsa.094430.1 PAC:16957740 Cucumis sativus 625  
Cucsa.094430.2 PAC:16957741 Cucumis sativus 614  
Cucsa.120120.1 PAC:16961085 Cucumis sativus 887  
Cucsa.120120.2 PAC:16961086 Cucumis sativus 813  
Cucsa.257660.1 A0A0A0L4D8 PAC:16972741 Cucumis sativus 691  
orange1.1g001454m A0A067GPF1 PAC:18107967 Citrus sinensis 1075  
orange1.1g001936m A0A067H1S4 PAC:18107968 Citrus sinensis 994  
orange1.1g003170m A0A067GS62 PAC:18107969 Citrus sinensis 842  
orange1.1g001097m A0A067GP66 PAC:18107963 Citrus sinensis 1158  
orange1.1g001164m A0A067H1B4 PAC:18107964 Citrus sinensis 1134  
orange1.1g001220m A0A067GS58 PAC:18107965 Citrus sinensis 1121  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11493912
            12897056