Protein Domain : IPR010979

Type:  Domain Name:  Ribosomal protein S13-like, H2TH
Description:  Ribosomal protein S13 is one of the proteins from the small ribosomal subunit []. In Escherichia coli, S13 is known to be involved in binding fMet-tRNA and, hence, in the initiation of translation. S13 contains thee helices and a beta-hairpin in the core of the protein, which form a helix-two turns-helix (H2TH) motif, and a non-globular C-terminal extension.This H2TH motif can be found in other proteins as well. In the DNA repair protein, MutM (formamidopyrimidine DNA glycosylase; Fpg), the middle domain contains the H2TH motif. MutM is a trifunctional DNA base excision repair enzyme that removes a wide range of oxidatively damaged bases (N-glycosylase activity) and cleaves both the 3'- and 5'-phosphodiester bonds of the resulting apurinic/apyrimidinic site (AP lyase activity) []. Other repair enzymes, such as E. coli Endonuclease VIII that excises oxidized pyrimidines from DNA, also contain a DNA-binding H2TH motif within the middle domain. The H2TH domains of these repair proteins are only peripherally involved in binding DNA; their primary function may be simply to position the N-terminal lobe and C-terminal zinc finger domain of the glycosylases for interactions with DNA.The middle domain of topoisomerase IV-B subunit contains a H2TH motif that is structurally related to the DNA repair proteins. Although the H2TH domain appears to be retained in all archaeal and plant type IIB topoisomerases identified to date, it has no known function and has not been observed in other topoisomerase families []. Short Name:  Ribosomal_S13-like_H2TH

1 Child Features

DB identifier Type Name
IPR015886 Domain DNA glycosylase/AP lyase, H2TH DNA-binding

1 Contains

DB identifier Type Name
IPR018269 Conserved_site Ribosomal protein S13, conserved site

1 Cross References

Identifier
SSF46946

2 Found Ins

DB identifier Type Name
IPR005734 Family DNA topoisomerase VI, subunit B
IPR020629 Family Formamidopyrimidine-DNA glycosylase

1 GO Annotation

GO Term Gene Name
GO:0003676 IPR010979

1 Ontology Annotations

GO Term Gene Name
GO:0003676 IPR010979

0 Parent Features

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
92654 D8RF35 PAC:15419953 Selaginella moellendorffii 655  
267619 D8RPT9 PAC:15412728 Selaginella moellendorffii 156  
140847 D8QSU4 PAC:15409809 Selaginella moellendorffii 163  
75016 D8QNL5 PAC:15409644 Selaginella moellendorffii 268  
75308 D8QR07 PAC:15411956 Selaginella moellendorffii 113  
evm.model.supercontig_167.9 PAC:16410497 Carica papaya 267  
evm.model.supercontig_26.84 PAC:16415329 Carica papaya 152  
evm.model.supercontig_26.83 PAC:16415328 Carica papaya 161  
evm.model.supercontig_263.25 PAC:16415389 Carica papaya 116  
evm.model.supercontig_36.2 PAC:16418392 Carica papaya 251  
evm.model.supercontig_36.3 PAC:16418413 Carica papaya 168  
evm.model.supercontig_58.110 PAC:16422953 Carica papaya 152  
evm.model.supercontig_84.111 PAC:16427273 Carica papaya 703  
29841.m002895 B9RVA4 PAC:16810608 Ricinus communis 403  
29863.m001096 B9SEC1 PAC:16811718 Ricinus communis 152  
29908.m006203 B9RJA5 PAC:16813020 Ricinus communis 290  
30169.m006390 B9RI75 PAC:16821190 Ricinus communis 656  
50483.m000020 B9TPV6 PAC:16828272 Ricinus communis 223  
29647.m002061 B9S400 PAC:16804705 Ricinus communis 152  
Cucsa.363910.1 PAC:16981168 Cucumis sativus 152  
Cucsa.026260.3 PAC:16952057 Cucumis sativus 116  
Cucsa.026260.4 PAC:16952058 Cucumis sativus 116  
Cucsa.026260.5 PAC:16952059 Cucumis sativus 116  
Cucsa.026260.1 A0A0A0KMX9 PAC:16952055 Cucumis sativus 148  
Cucsa.026260.2 PAC:16952056 Cucumis sativus 116  
Cucsa.079620.1 PAC:16956236 Cucumis sativus 152  
Cucsa.079620.2 PAC:16956237 Cucumis sativus 152  
Cucsa.079620.3 PAC:16956238 Cucumis sativus 118  
Cucsa.096060.2 PAC:16957978 Cucumis sativus 310  
Cucsa.096060.1 A0A0A0KWY6 PAC:16957977 Cucumis sativus 402  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10921868
            12464183
            12505993