Protein Domain : IPR020629

Type:  Family Name:  Formamidopyrimidine-DNA glycosylase
Description:  Formamidopyrimidine-DNA glycosylase (Fpg, MutM) is a trifunctional DNA base excision repair enzyme that removes a wide range of oxidation-damaged bases (N-glycosylase activity; ) and cleaves both the 3'- and 5'-phosphodiester bonds of the resulting apurinic/apyrimidinic site (AP lyase activity; ). Fpg has a preference for oxidised purines, excising oxidized purine bases such as 7,8-dihydro-8-oxoguanine (8-oxoG). ITs AP (apurinic/apyrimidinic) lyase activity introduces nicks in the DNA strand, cleaving the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Fpg is a monomer composed of 2 domains connected by a flexible hinge []. The two DNA-binding motifs (a zinc finger and the helix-two-turns-helix motifs) suggest that the oxidized base is flipped out from double-stranded DNA in the binding mode and excised by a catalytic mechanism similar to that of bifunctional base excision repair enzymes []. Fpg binds one ion of zinc at the C terminus, which contains four conserved and essential cysteines [, ]. Short Name:  Formamido-pyr_DNA_Glyclase
Paste the following link

0 Child Features

6 Contains

DB identifier Type Name
IPR010663 Domain Zinc finger, FPG/IleRS-type
IPR010979 Domain Ribosomal protein S13-like, H2TH
IPR015886 Domain DNA glycosylase/AP lyase, H2TH DNA-binding
IPR012319 Domain Formamidopyrimidine-DNA glycosylase, catalytic domain
IPR000214 Domain Zinc finger, DNA glycosylase/AP lyase-type
IPR015887 Binding_site DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site

2 Cross Referencess

Identifier
TIGR00577
MF_00103

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003906 IPR020629
GO:0008270 IPR020629
GO:0008534 IPR020629
GO:0006281 IPR020629

4 Ontology Annotations

GO Term Gene Name
GO:0003906 IPR020629
GO:0008270 IPR020629
GO:0008534 IPR020629
GO:0006281 IPR020629

0 Parent Features

526 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
evm.model.supercontig_167.9 PAC:16410497 Carica papaya 267  
29841.m002895 B9RVA4 PAC:16810608 Ricinus communis 403  
Cucsa.096060.1 A0A0A0KWY6 PAC:16957977 Cucumis sativus 402  
orange1.1g024924m A0A067DI67 PAC:18116736 Citrus sinensis 260  
orange1.1g015345m A0A067DE50 PAC:18116733 Citrus sinensis 408  
orange1.1g022931m A0A067DRM4 PAC:18116735 Citrus sinensis 290  
orange1.1g022922m A0A067DRM4 PAC:18116734 Citrus sinensis 290  
AT1G52500.2 O80358 PAC:19649590 Arabidopsis thaliana 390  
AT1G52500.1 O80358 PAC:19649591 Arabidopsis thaliana 274  
Thhalv10011553m V4KG95 PAC:20184860 Eutrema salsugineum 397  
Ciclev10025737m V4SP53 PAC:20799684 Citrus clementina 408  
Potri.003G031100.1 U5GP93 PAC:27000161 Populus trichocarpa 407  
Potri.003G031100.2 A0A2K2B0U0 PAC:27000162 Populus trichocarpa 406  
Gorai.011G089400.1 A0A0D2UR55 PAC:26807973 Gossypium raimondii 464  
Gorai.011G089400.2 A0A0D2T4U5 PAC:26807974 Gossypium raimondii 413  
Gorai.011G089400.4 A0A0D2UQ25 PAC:26807975 Gossypium raimondii 327  
Gorai.011G089400.5 A0A0D2VK44 PAC:26807977 Gossypium raimondii 265  
Gorai.011G089400.3 A0A0D2RJ46 PAC:26807976 Gossypium raimondii 301  
46879 I0Z1U9 PAC:27387145 Coccomyxa subellipsoidea C-169 373  
Thecc1EG027275t2 A0A061G903 PAC:27440950 Theobroma cacao 409  
Thecc1EG027275t3 A0A061GFT6 PAC:27440951 Theobroma cacao 408  
Thecc1EG027275t1 A0A061G9S4 PAC:27440949 Theobroma cacao 416  
Migut.I00747.2.p A0A022PZB0 PAC:28931453 Mimulus guttatus 438  
Migut.I00747.1.p PAC:28931452 Mimulus guttatus 439  
Araha.4486s0005.1.p PAC:28846286 Arabidopsis halleri 390  
Cagra.4237s0018.1.p PAC:28898071 Capsella grandiflora 396  
Glyma.13G366800.1.p I1M5V4 PAC:30504707 Glycine max 399  
Brara.E01577.1.p A0A397ZC08 PAC:30625343 Brassica rapa FPsc 388  
Bostr.0124s0038.1.p PAC:30656306 Boechera stricta 396  
Medtr2g104100.1 G7II90 PAC:31063095 Medicago truncatula 396  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8473347
            7704272
            10921868