Type: | Family | Name: | Peptidyl-prolyl cis-trans isomerase, FKBP-type |
Description: | Synonym(s): Peptidylprolyl cis-trans isomeraseFKBP-type peptidylprolyl isomerases () in vertebrates, are receptors for the two immunosuppressants, FK506 and rapamycin. The drugs inhibit T cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. Peptidylprolyl isomerases accelerate protein folding by catalysing the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides. These proteins are found in a variety of organisms. | Short Name: | PPIase_FKBP |