Protein Domain : IPR017383

Type:  Family Name:  Actin-related protein 2/3 complex subunit 1
Description:  Arp2/3 binds to pre-existing actin filaments and nucleates new daughter filaments, and thus becomes incorporated into the dynamic actin network at the leading edge of motile cells and other actin-based protrusive structures []. In order to nucleate filaments, Arp2/3 must bind to a member of the N-WASp/SCAR family protein []. Arp2 and Arp3 are thought to be brought together after activation, forming an actin-like nucleus for actin monomers to bind and create a new actin filament. In the absence of an activating protein, Arp2/3 shows very little nucleation activity. Recent research has focused on the binding and hydrolysis of ATP by Arp2 and Arp3 [], and crystal structures of the Arp2/3 complex have been solved [].The human Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. This family represents the ARPC1/p41-ARC subunit. Short Name:  ARPC1
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2 Child Features

DB identifier Type Name
IPR030141 Family Actin-related protein 2/3 complex subunit 1B
IPR030140 Family Actin-related protein 2/3 complex subunit 1A

3 Contains

DB identifier Type Name
IPR015943 Domain WD40/YVTN repeat-like-containing domain
IPR001680 Repeat WD40 repeat
IPR017986 Domain WD40-repeat-containing domain

2 Cross Referencess

Identifier
PTHR10709
PIRSF038093

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0030833 IPR017383
GO:0034314 IPR017383
GO:0005885 IPR017383
GO:0015629 IPR017383

4 Ontology Annotations

GO Term Gene Name
GO:0030833 IPR017383
GO:0034314 IPR017383
GO:0005885 IPR017383
GO:0015629 IPR017383

0 Parent Features

572 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
140479 D8QRC4 PAC:15406755 Selaginella moellendorffii 381  
evm.model.supercontig_50.61 PAC:16421684 Carica papaya 305  
29636.m000755 B9SIS1 PAC:16804356 Ricinus communis 386  
Cucsa.185260.1 A0A0A0KHX9 PAC:16967671 Cucumis sativus 379  
orange1.1g016982m A0A067EU28 PAC:18130555 Citrus sinensis 379  
AT2G30910.2 F4IPT5 PAC:19642420 Arabidopsis thaliana 378  
AT2G31300.1 Q9SJW6 PAC:19638866 Arabidopsis thaliana 378  
AT2G30910.3 O80856 PAC:19642421 Arabidopsis thaliana 378  
AT2G30910.1 O80856 PAC:19642419 Arabidopsis thaliana 378  
Thhalv10017010m V4LM13 PAC:20180119 Eutrema salsugineum 296  
Thhalv10017625m V4MGH5 PAC:20181038 Eutrema salsugineum 327  
Ciclev10015915m V4UG39 PAC:20816151 Citrus clementina 326  
Ciclev10015615m V4U5S0 PAC:20816150 Citrus clementina 379  
Lus10031375 PAC:23155851 Linum usitatissimum 387  
Potri.014G141700.2 PAC:27035368 Populus trichocarpa 347  
Potri.014G141700.1 B9IA44 PAC:27035367 Populus trichocarpa 378  
Gorai.011G123100.1 A0A0D2VLJ8 PAC:26812068 Gossypium raimondii 377  
39324 I0ZAS0 PAC:27389076 Coccomyxa subellipsoidea C-169 302  
Thecc1EG001800t1 A0A061DJX7 PAC:27433898 Theobroma cacao 377  
Thecc1EG001800t2 A0A061DLI1 PAC:27433899 Theobroma cacao 263  
Migut.D00514.1.p A0A022S272 PAC:28929012 Mimulus guttatus 379  
Araha.1786s0012.1.p PAC:28853538 Arabidopsis halleri 378  
Cagra.3217s0014.1.p PAC:28908320 Capsella grandiflora 378  
Glyma.08G311700.1.p K7LA18 PAC:30537926 Glycine max 376  
Glyma.10G216300.1.p I1LD74 PAC:30478218 Glycine max 376  
Glyma.10G216300.4.p I1LD75 PAC:30478221 Glycine max 351  
Glyma.10G216300.3.p I1LD75 PAC:30478220 Glycine max 351  
Glyma.10G216300.2.p I1LD74 PAC:30478219 Glycine max 376  
Glyma.18G103800.1.p I1N0U4 PAC:30557160 Glycine max 376  
Brara.D01854.1.p A0A397ZUZ3 PAC:30620376 Brassica rapa FPsc 130  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9889097
            15505213
            9600938
            11752435