Protein Domain : IPR017986

Type:  Domain Name:  WD40-repeat-containing domain
Description:  WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs, often terminating in a Trp-Asp (W-D) dipeptide. WD40 repeats usually assume a 7-8 bladed beta-propeller fold, but proteins have been found with 4 to 16 repeated units, which also form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. Repeated WD40 motifs act as a site for protein-protein interaction, and proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller), TAFII transcription factor, and E3 ubiquitin ligase [, ]. In Arabidopsis spp., several WD40-containing proteins act as key regulators of plant-specific developmental events.This entry identifies a domain containing adjacent WD repeats. Short Name:  WD40_repeat_dom
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0 Child Features

3 Contains

DB identifier Type Name
IPR001680 Repeat WD40 repeat
IPR001632 Domain G-protein, beta subunit
IPR019775 Conserved_site WD40 repeat, conserved site

2 Cross Referencess

Identifier
PS50294
SSF50978

13 Found Ins

DB identifier Type Name
IPR017383 Family Actin-related protein 2/3 complex subunit 1
IPR004083 Family Regulatory associated protein of TOR
IPR016453 Family Coatomer beta' subunit (COPB2)
IPR016346 Family Guanine nucleotide-binding protein, beta subunit
IPR017399 Family WD repeat protein DCAF11/LEC14B
IPR016391 Family Coatomer alpha subunit
IPR017422 Family WD repeat protein 55
IPR017233 Family WD repeat protein 35
IPR017251 Family Apoptotic protease-activating factor 1
IPR017149 Family Glutathione degradosome, DUG2
IPR009146 Family Groucho/transducin-like enhancer
IPR017252 Family Dynein regulator LIS1
IPR015505 Family Coronin

1 GO Annotation

GO Term Gene Name
GO:0005515 IPR017986

1 Ontology Annotations

GO Term Gene Name
GO:0005515 IPR017986

1 Parent Features

DB identifier Type Name
IPR015943 Domain WD40/YVTN repeat-like-containing domain

138300 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
134659 D8T8U4 PAC:15412813 Selaginella moellendorffii 202  
146931 D8RGA6 PAC:15405712 Selaginella moellendorffii 307  
146851 D8RG20 PAC:15404961 Selaginella moellendorffii 339  
171237 D8RG90 PAC:15407276 Selaginella moellendorffii 1207  
171199 D8RG53 PAC:15406720 Selaginella moellendorffii 1283  
33764 D8RFG2 PAC:15402730 Selaginella moellendorffii 263  
71495 D8RFA5 PAC:15423427 Selaginella moellendorffii 206  
92496 D8RG57 PAC:15418528 Selaginella moellendorffii 1180  
92939 D8RFV8 PAC:15422090 Selaginella moellendorffii 419  
171333 D8RGE3 PAC:15408036 Selaginella moellendorffii 646  
171378 D8RGP7 PAC:15408156 Selaginella moellendorffii 404  
171375 D8RGP5 PAC:15408153 Selaginella moellendorffii 413  
147078 D8RGS8 PAC:15401915 Selaginella moellendorffii 481  
431142 D8TBN3 PAC:15420688 Selaginella moellendorffii 254  
441252 D8RHZ8 PAC:15406340 Selaginella moellendorffii 2376  
94452 D8RHT5 PAC:15401956 Selaginella moellendorffii 318  
412471 D8RLK7 PAC:15411631 Selaginella moellendorffii 2052  
412737 D8RLB3 PAC:15413934 Selaginella moellendorffii 715  
441729 D8RLC3 PAC:15410169 Selaginella moellendorffii 389  
96537 D8RLJ0 PAC:15408460 Selaginella moellendorffii 391  
165451 D8QUP7 PAC:15413519 Selaginella moellendorffii 745  
404454 D8QVD7 PAC:15410252 Selaginella moellendorffii 617  
404377 D8QV48 PAC:15409497 Selaginella moellendorffii 833  
77968 D8QUM2 PAC:15422428 Selaginella moellendorffii 816  
63950 D8QU35 PAC:15403478 Selaginella moellendorffii 379  
63947 D8QV50 PAC:15403463 Selaginella moellendorffii 379  
78512 D8QUS0 PAC:15422128 Selaginella moellendorffii 515  
78344 D8QW94 PAC:15420780 Selaginella moellendorffii 554  
78691 D8QUF4 PAC:15423096 Selaginella moellendorffii 900  
79168 D8QUI0 PAC:15422117 Selaginella moellendorffii 695  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10322433
            11814058