Protein Domain : IPR019775

Type:  Conserved_site Name:  WD40 repeat, conserved site
Description:  WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs, often terminating in a Trp-Asp (W-D) dipeptide. WD40 repeats usually assume a 7-8 bladed beta-propeller fold, but proteins have been found with 4 to 16 repeated units, which also form a circularised beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes and are implicated in a variety of functions ranging from signal transduction and transcription regulation to cell cycle control and apoptosis. Repeated WD40 motifs act as a site for protein-protein interaction, and proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. The specificity of the proteins is determined by the sequences outside the repeats themselves. Examples of such complexes are G proteins (beta subunit is a beta-propeller), TAFII transcription factor, and E3 ubiquitin ligase [, ]. In Arabidopsis spp., several WD40-containing proteins act as key regulators of plant-specific developmental events.This entry represents a conserved site found in the WD40 repeat. Short Name:  WD40_repeat_CS
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0 Child Features

0 Contains

1 Cross References

Identifier
PS00678

13 Found Ins

DB identifier Type Name
IPR015943 Domain WD40/YVTN repeat-like-containing domain
IPR001680 Repeat WD40 repeat
IPR017986 Domain WD40-repeat-containing domain
IPR001632 Domain G-protein, beta subunit
IPR000009 Family Protein phosphatase 2A regulatory subunit PR55
IPR016346 Family Guanine nucleotide-binding protein, beta subunit
IPR016391 Family Coatomer alpha subunit
IPR017422 Family WD repeat protein 55
IPR017251 Family Apoptotic protease-activating factor 1
IPR017149 Family Glutathione degradosome, DUG2
IPR000664 Family Lethal(2) giant larvae protein
IPR017252 Family Dynein regulator LIS1
IPR015505 Family Coronin

0 GO Annotation

0 Ontology Annotations

0 Parent Features

0 Proteins

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10322433
            11814058