Protein Domain : IPR003172

Type:  Domain Name:  MD-2-related lipid-recognition domain
Description:  The MD-2-related lipid-recognition (ML) domain is implicated in lipid recognition, particularly in the recognition of pathogen related products. It has an immunoglobulin-like beta-sandwich fold similar to that of E-set Ig domains. This domain is present in proteins from plants, animals and fungi, including the following proteins: Epididymal secretory protein E1 (also known as Niemann-Pick C2 protein), which is known to bind cholesterol. Niemann-Pick disease type C2 is a fatal hereditary disease characterised by accumulation of low-density lipoprotein-derived cholesterol in lysosomes [].House-dust mite allergen proteins such as Der f 2 from Dermatophagoides farinaeand Der p 2 from Dermatophagoides pteronyssinus[]. Short Name:  ML_dom
Paste the following link

0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF02221
SM00737
G3DSA:2.60.40.770

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR014756 Domain Immunoglobulin E-set

3256 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
69362 D8QRK8 PAC:15416513 Selaginella moellendorffii 109  
77082 D8QRK9 PAC:15415716 Selaginella moellendorffii 118  
evm.model.supercontig_103.28 PAC:16404911 Carica papaya 195  
evm.model.supercontig_1467.2 PAC:16409178 Carica papaya 152  
29854.m001129 B9RQ54 PAC:16811641 Ricinus communis 142  
29333.m001066 B9SDL0 PAC:16802680 Ricinus communis 155  
Cucsa.356090.1 PAC:16980260 Cucumis sativus 190  
Cucsa.356090.2 PAC:16980261 Cucumis sativus 164  
Cucsa.242020.1 PAC:16971098 Cucumis sativus 149  
orange1.1g031744m PAC:18118263 Citrus sinensis 153  
orange1.1g032014m A0A067ECL5 PAC:18111739 Citrus sinensis 149  
orange1.1g032005m A0A067E504 PAC:18111723 Citrus sinensis 149  
orange1.1g033390m A0A067EDG1 PAC:18111724 Citrus sinensis 120  
orange1.1g031870m A0A067E1I9 PAC:18111738 Citrus sinensis 151  
AT5G06480.1 Q9FG22 PAC:19672430 Arabidopsis thaliana 153  
AT5G23840.2 F4KEB4 PAC:19667524 Arabidopsis thaliana 140  
AT5G23840.1 Q9FF96 PAC:19667523 Arabidopsis thaliana 167  
AT5G23830.1 Q9FF97 PAC:19671642 Arabidopsis thaliana 164  
AT5G23830.2 B3H438 PAC:19671643 Arabidopsis thaliana 161  
AT5G23820.1 Q9FF98 PAC:19670380 Arabidopsis thaliana 164  
AT3G11780.2 F4J7G5 PAC:19663292 Arabidopsis thaliana 171  
AT3G11780.1 Q9SF20 PAC:19663293 Arabidopsis thaliana 153  
AT3G44100.1 Q9LXQ2 PAC:19659519 Arabidopsis thaliana 152  
AT1G45015.2 F4HPM2 PAC:19650671 Arabidopsis thaliana 142  
AT1G45015.1 Q9MAK7 PAC:19650670 Arabidopsis thaliana 153  
AT2G26370.1 O48704 PAC:19638235 Arabidopsis thaliana 173  
AT2G16005.1 Q9AST8 PAC:19638867 Arabidopsis thaliana 160  
Thhalv10021698m V4LYD1 PAC:20183861 Eutrema salsugineum 152  
Thhalv10010794m V4NI91 PAC:20206976 Eutrema salsugineum 152  
Thhalv10014916m V4LJZ6 PAC:20206020 Eutrema salsugineum 153  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12591954
            15710415